Inventors:
Leszek Kotula - Marlboro NJ, US
Xiaoling Xiong - Fresh Meadows NY, US
International Classification:
A61K 38/16, C07K 7/08, C07K 14/00, C07K 17/00, A61K 38/10, A61P 35/00
US Classification:
514 12, 530327, 530324, 530350, 514 14
Abstract:
Provided are purified compounds comprising SEQ ID NO:1, where the tyrosine at residue (10) is phosphorylated. Also provided are purified compounds comprising SEQ ID NO:1, where the amino acid sequence of the compound is less than 400 amino acids. Additionally provided are methods of determining whether an agent is a candidate inhibitor of an Abl kinase. Further provided are methods of inhibiting an Abl kinase. Also provided are methods of treating a patient having a condition characterized by a mutant AbI kinase. Additionally provided are methods of treating a patient at risk for a condition characterized by a mutant AbI kinase. Methods of labeling an AbI kinase are also provided. Additionally, methods of isolating an Abl kinase from a tissue are provided.