XIAOLING QU, NP
Nursing in Cleveland, OH
License number
Ohio 020185
Category
Nursing
Type
Family
Address
Address
11100 Uh Rainbow Babies & CHILDREN'S HOSPITAL SUITE 380, Cleveland, OH 44106
Phone
(216) 844-3528
Professional information
Method For Detecting And Purifying Pancreatic Beta Cells
US Patent:
2012007, Mar 22, 2012
Filed:
Nov 5, 2009
Appl. No.:
13/128181
Inventors:
Jan Jensen - Shaker Heights OH, US
John Hutton - Aurora CO, US
Xiaoling Qu - Beachwood OH, US
Howard Davidson - Denver CO, US
John Hutton - Aurora CO, US
Xiaoling Qu - Beachwood OH, US
Howard Davidson - Denver CO, US
International Classification:
G01N 33/566, C12Q 1/02, C07K 16/28, C12N 5/071, C07H 21/04, C07K 14/705
US Classification:
435 721, 536 235, 530350, 5303879, 435325, 435 29
Abstract:
The invention is based, in part, on the discovery that a polypeptide, referred to herein as Betacam, is selectively expressed on the surface of pancreatic islet cells, Thus, in one aspect, the invention is directed to compositions comprising Betacam or that can be used to detect Betacam. In another aspect, the invention provides methods of detecting (e.g., non-invasively) pancreatic beta cells from a mammalian cell source. Another aspect of the invention is directed to cellular purification of pancreatic beta cells from a heterogeneous cell source of multiple kinds. In another aspect, the invention provides methods of identifying agents that modulate activity of Betacam-In yet another aspect, the invention provides for improved treatment and diagnosis of diabetes.