Inventors:
Mina Aikawa - Emeryville CA, US
Payman Amiri - Emeryville CA, US
Steven Bashman - Emeryville CA, US
Jeffrey Dove - Emeryville CA, US
Rama Jain - Emeryville CA, US
Xiaodong Lin - Emeryville CA, US
Jeremy Murray - Emeryville CA, US
Savithri Ramurthy - Emeryville CA, US
Alice Rico - Emeryville CA, US
Wei Shu - Emeryville CA, US
Sharadha Subramanian - Emeryville CA, US
Xiaojing Michael Wang - Emeryville CA, US
Robert L. Warne - Emeryville CA, US
Yasheen Zhou - Emeryville CA, US
International Classification:
A61K 31/337, C07D 239/84, A61K 31/517, C07D 401/12, A61K 31/496, C07D 403/10, C07D 413/10, A61K 31/5377, C07D 413/14, C07D 403/12, A61P 35/00
US Classification:
51421021, 544292, 5142664, 544284, 51426621, 51425217, 544359, 544122, 5142345, 5142325, 544 80, 548952
Abstract:
The invention provides novel compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.