XIAODONG WU
Technologists at 12 Ave, Miami, FL

7780349, Aug 24, 2010

Jan 3, 2008

12/006629

Xiaodong Wu - Miami FL, US

A61B 6/08, A61N 5/10

378205, 378 65, 378163

A method and apparatus for quality assurance of beam geometry of robotic radiosurgery systems. The apparatus comprises two or more radio-opaque markers set at a fixed distance from each other and contained in a housing, which is assembled to a collimator fixture for attachment to the collimator interface of the LINAC of a robotic radiosurgery system. A treatment plan is generated to position the LINAC to a series of pre-defined radiation beam orientations, then a simulation of the treatment is carried out, and radiographic images are taken at each LINAC position. The coordinates of the radio-opaque markers obtained from the images are used to determine beam orientation by calculating their directional cosines, the beam off-axis error and the deviation of the radiation source to iso-center distance (SAD). The imaging system is independently calibrated and the quantitative beam geometric information is used to adjust beam geometry for quality assurance.

6641518, Nov 4, 2003

Apr 24, 2001

09/840454

Aaron Wolfson - Plantation FL
Xiaodong Wu - Miami FL

The University of Miami - Miami FL

A61N 500

600 6, 600 1, 600 3, 604515

A multicomponent vaginal cylinder system composed of a tandem capable of housing one or more radiation sources, one or more removable ovoid cartridges, each cartridge capable of housing a radiation source, and a vaginal cylinder structure having corresponding hollow cavities to accommodate the insertions of the tandem and the ovoid cartridges. Radiation shielding may be removably attached to portions of the vaginal cylinder structure to shield tissues from unwanted radiation. A method for using this vaginal cylinder system to treat gynecological cancers is also disclosed.

2008021, Sep 11, 2008

Mar 9, 2008

12/045000

Xiaodong Wu - Miami FL, US

A61B 6/00, H05G 1/00

378 4, 378208

A method and apparatus for precisely reproducing the position of a vaginal cylinder in relation to a patient to ensure that a planned radiation dose can be delivered with high precision to the intended treatment target volumes. In order to properly define the treatment volume, a vaginal cylinder with proper diameter is inserted into the patient's vagina. This invention addresses two potential errors: one, the incorrect vaginal cylinder position in relation to the radiation beams, and second, the inconsistent positional correlation between the vaginal cylinder and the patient's body. These two geometric errors will cause dosimetric errors. The present invention provides a method and apparatus for minimizing the geometric error and dosimetric error associated with conventional external beam radiation therapy or radiosurgery used in treating gynecological tumors. First a treatment plan is carried out to determine the treatment target volume. Second, treatment delivery is carried out by using an image-guided system to locate the position of the vaginal cylinder and comparing it relative to the treatment delivery system coordinate system and the patient's coordinate system. The displacement in the position of the vaginal cylinder from the treatment plan is corrected by calculating the transformation matrix and entering the resulting value into a position adjusting assembly. The position adjusting assembly adjusts the vaginal cylinder to exactly reproduce its location relative to the patient's coordinate system. This ensures that the image-guided system locates the precise radiation delivery position and that the radiation dose is delivered precisely to the treatment target volume.

7531810, May 12, 2009

Aug 4, 2006

11/499380

Xiaodong Wu - Miami FL, US

G01K 1/08, H01J 3/14, H01J 3/26

250375, 2504911, 250583, 250585, 250378, 600 1, 600 3, 600417, 600114, 600410, 600407, 600427, 607130, 607129, 607108, 607131, 607 14, 378 65, 378158, 378205, 378123, 378119, 378121, 378 64, 378116, 378108, 378207

A method for routine monitoring and quality assurance of field asymmetry of high energy circular radiation beam producing equipment. The quality assurance process of field symmetry for devices such as stereotactic radiosurgery (SRS) systems is simplified by directly measuring the integration of the half-beam profile. The method of the invention provides that the field symmetry is obtained by positioning the tip of an ion chamber, with a collecting length approximately half the diameter of the beam, at the central axis of the beam, and rotating the ion chamber at varying angular positions, acquiring and comparing readings at desired angular positions. Each pair of readings from positions 180 degrees opposed from each other, are plugged into the equation, Asymmetry=2(R−R)/(R+R) to compute asymmetry.

8395131, Mar 12, 2013

Jun 20, 2010

12/819212

Xiaodong Wu - Miami FL, US
Mansoor M. Ahmed - Miami FL, US
Alan Pollack - Miami FL, US

A61N 5/10

2504921, 372 64, 372 65

A method for high-dose Grid radiotherapy utilizing a three-dimensional (3D) dose lattice formation is described herein. The 3D dose lattice can be achieved by, but not limited to, three technical approaches: 1) non-coplanar focused beams; 2) multileaf collimator (MLC)-based intensity modulated radiation therapy (IMRT) or aperture-modulated arc; and 3) heavy charged particle beam. The configuration of a 3D dose lattice is comprised of the number, location, and dose of dose vertices. The optimal configuration of a 3D dose lattice can be achieved by manual calculations or by automating the calculations for a generic algorithm. The objective of the optimization algorithm is to satisfy three conditions via iteration until they reach their global minimum. With 3D dose lattice, high doses of radiation are concentrated at each lattice vertex within a tumor with drastically lower doses between vertices (peak-to-valley effect), leaving tissue outside of the tumor volume minimally exposed.

2013014, Jun 6, 2013

Jan 11, 2013

13/739318

University of Miami - Miami FL, US
Xiaodong WU - Miami FL, US
Seema GUPTA - Miami FL, US
Alan POLLACK - Miami FL, US

UNIVERSITY OF MIAMI - Miami FL

A61M 5/00

604131

The present invention provides for a biocompatible drug delivery device for the targeted treatment of cancer that is implantable within the tumorous mass of a patient. In one embodiment, the device comprises two polarizable elements mechanically coupled by a connecting element. The device also comprises one or more cancer treatment agents. When the polarizable elements are depolarized, such as by the application of ionizing radiation, the two polarizable elements are repelled from each other and release the cancer treatment agent. In another embodiment, one or more treatment agents are expelled from a miniaturized syringe when internal pressure of the device is increased by the production of gas bubbles in response to the application of ionizing radiation.

7789561, Sep 7, 2010

Feb 15, 2008

12/032628

Xiaodong Wu - Miami FL, US
Ricardo Garcia - Miami FL, US

A61B 6/08, A61N 5/10

378206, 378 65, 378207

A method and apparatus for verifying radiation beam alignment in an image guided stereotactic radiosurgery (SRS) delivery system such as the Cyberknife™. This invention achieves precise verification of radiation beam alignment with a radiation beam detection apparatus mounted on a gimbal assembly. The radiation beam detection apparatus houses an alignment fixture of varying geometric shape, such as a metallic ball or can be an array of radio-opaque markers positioned symmetrically at the gimbal assembly's common rotation center. The radiation detection apparatus comprises a radiation detector such as film and an alignment mirror, which are parallel to each other on opposite sides of the alignment fixture. The radiation detector is used to capture a radiographic image of the alignment fixture and the circular radiation field. The resulting image is analyzed to determine the eccentricity of the radiation field and whether adjustment of node positions is required to eliminate any eccentricity.

6127688, Oct 3, 2000

Feb 6, 1998

9/020004

Xiaodong Wu - Miami FL

The University of Miami - Miami FL

H01J 3709

2505051

This invention includes an iso-energetic intensity modulating filter and method for therapeutic charged-particle beams, preferably electron beams, in which attenuating members are arranged to completely attenuate portions of the beam while permitting other portions of the beam to pass through the space between attenuating members. The attenuating members block the charged particles without producing any significant bremsstrahlung contamination in the filtered beam. The attenuating members can be arranged in a large number of configurations to obtain the desired modulated beam intensity profile. This invention also includes an improved iso-energetic, intensity-modulated charged-particle beam produced by the filtering device and method of this invention. A charged-particle beam therapeutic device and treatment method which has the iso-energetic intensity modulating filter is also included in this invention.