XI HE
Accountancy in Boston, MA
License number
Massachusetts 32797
Issued Date
Nov 12, 2015
Expiration Date
Jun 30, 2017
Type
Certified Public Accountant
Address
Address
Boston, MA 02116
Professional information
Professor At Children's Hospital Boston
Location:
Greater Boston Area
Industry:
Higher Education
Polynucleotides Encoding Human Frp And Fragments Thereof
US Patent:
6479255, Nov 12, 2002
Filed:
May 29, 1998
Appl. No.:
09/087031
Inventors:
Jeffrey S. Rubin - Rockville MD
Paul Finch - Croton NY
Stuart Aaronson - New York NY
Xi He - Brighton MA
Paul Finch - Croton NY
Stuart Aaronson - New York NY
Xi He - Brighton MA
Assignee:
The United States of America as represented by the Secretary of the Department of Health and Human Services - Washington DC
International Classification:
C12P 2106
US Classification:
435 691, 536 235, 530350, 4353201, 4352523, 435 6
Abstract:
The invention provides a novel, secreted protein that contains a region homologous to ligand binding domain of a cytokine receptor. This protein, called Frizzled-related protein (FRP), antagonizes the signaling of the Wnt family of cytokines. Extracellular signaling molecules such as the Wnt family members have essential roles as inducers of cellular proliferation, migration, differentiation, and tissue morphogenesis. As Wnt molecules are known to participate in the aberrant growth associated with neoplasia, Wnt antagonists such as FRP are valuable tools which both for understanding oncogenesis and for the design of new cancer therapies.
Human Frp And Fragments Thereof Including Methods For Using Them
US Patent:
7183377, Feb 27, 2007
Filed:
May 3, 2002
Appl. No.:
10/138434
Inventors:
Jeffrey S. Rubin - Rockville MD, US
Paul Finch - Croton NY, US
Stuart Aaronson - New York NY, US
Xi He - Brighton MA, US
Paul Finch - Croton NY, US
Stuart Aaronson - New York NY, US
Xi He - Brighton MA, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
C07K 14/705
US Classification:
530350, 5303873, 530402, 536 235, 536 234, 435 691, 435 697, 424 141
Abstract:
The invention provides a novel, secreted protein that contains a region homologous to ligand binding domain of a cytokine receptor. This protein, called Frizzled-related protein (FRP), antagonizes the signaling of the Wnt family of cytokines. Extracellular signaling molecules such as the Wnt family members have essential roles as inducers of cellular proliferation, migration, differentiation, and tissue morphogenesis. As Wnt molecules are known to participate in the aberrant growth associated with neoplasia, Wnt antagonists such as FRP are valuable tools which both for understanding oncogenesis and for the design of new cancer therapies.
Tiki1 And Tiki2, Wnt Inhibitors
US Patent:
2011023, Sep 22, 2011
Filed:
Mar 16, 2011
Appl. No.:
13/049436
Inventors:
Xi He - Jamaica Plain MA, US
Chika Yokota - Stockholm, SE
Xinjun Zhang - Brookline MA, US
Bryan MacDonald - Brookline MA, US
Chika Yokota - Stockholm, SE
Xinjun Zhang - Brookline MA, US
Bryan MacDonald - Brookline MA, US
International Classification:
A61K 38/17, C07K 14/435, C07H 21/00, C07K 16/00, A61K 31/7088, A61K 31/713, A61P 19/10, A61P 35/00, C12Q 1/02, C12N 15/63, C12N 1/00, C12N 5/10, A01K 67/00
US Classification:
800 13, 530350, 536 235, 5303879, 514 212, 514 44 R, 514 193, 514 44 A, 435 29, 4353201, 435243, 435325
Abstract:
This invention relates to Tiki1 and Tiki2 proteins and nucleic acids, cells expressing the same, and methods for identifying compounds that modulate Tiki1/2 activity for use in the treatment of osteoporosis or cellular proliferative disorders.