DR. WOLFRAM GOESSLING, MD PHD
Osteopathic Medicine at Brookline Ave, Boston, MA
License number
Massachusetts 203754
Category
Osteopathic Medicine
Type
Internal Medicine
Address
Address
450 Brookline Ave, Boston, MA 02215
Phone
(617) 632-3474
(617) 632-2260 (Fax)
(617) 632-2260 (Fax)
Organization information
See more information about WOLFRAM GOESSLING at bizstanding.comWolfram Goessling MD,PHD
75 Francis St, Boston, MA 02115
Industry:
Internist
Phone:
(617) 732-6389 (Phone)
Wolfram Goessling
Wolfram Goessling MD
450 Brookline Ave, Boston, MA 02215
Categories:
Physicians & Surgeons
Phone:
(617) 582-4300 (Phone)
Professional information
Wolfram Goessling, Boston MA
Specialties:
Gastroenterologist
Address:
450 Brookline Ave, Boston, MA 02215
Education:
Doctor of Medicine
Board certifications:
American Board of Internal Medicine Sub-certificate in Gastroenterology (Internal Medicine), American Board of Internal Medicine Sub-certificate in Oncology (Internal Medicine)
Assistant Professor At Brigham And Women's Hospital
Location:
Greater Boston Area
Industry:
Research
Assistant Professor At Brigham And Women's Hospital
Location:
Greater Boston Area
Industry:
Research
Methods For Promoting Hematopoietic Reconstitution
US Patent:
8563310, Oct 22, 2013
Filed:
Mar 27, 2012
Appl. No.:
13/431499
Inventors:
Leonard I. Zon - Wellesley MA, US
Trista E. North - Newton Center MA, US
Wolfram Goessling - Chestnut Hill MA, US
Trista E. North - Newton Center MA, US
Wolfram Goessling - Chestnut Hill MA, US
Assignee:
Children's Medical Center Corporation - Boston MA
The General Hospital Corporation - Boston MA
The General Hospital Corporation - Boston MA
International Classification:
C12N 5/00, C12N 5/02
US Classification:
435375, 435377
Abstract:
The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E(PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.
Methods For Promoting Hsc Engraftment
US Patent:
2013021, Aug 22, 2013
Filed:
Mar 15, 2013
Appl. No.:
13/838002
Inventors:
CHILDREN'S MEDICAL CENTER CORPORATION - , US
THE GENERAL HOSPITAL CORPORATION - , US
Wolfram Goessling - Chestnut Hill MA, US
THE GENERAL HOSPITAL CORPORATION - , US
Wolfram Goessling - Chestnut Hill MA, US
Assignee:
THE GENERAL HOSPITAL CORPORATION - Boston MA
CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA
CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA
International Classification:
A61K 35/14
US Classification:
424 937
Abstract:
The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E(PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.
Methods For Promoting Hsc Engraftment
US Patent:
8551782, Oct 8, 2013
Filed:
Mar 27, 2012
Appl. No.:
13/431534
Inventors:
Leonard I. Zon - Wellesley MA, US
Trista E. North - Newton Center MA, US
Wolfram Goessling - Chestnut Hill MA, US
Trista E. North - Newton Center MA, US
Wolfram Goessling - Chestnut Hill MA, US
Assignee:
Children's Medical Center Corporation - Boston MA
The General Hospital Corporation - Boston MA
The General Hospital Corporation - Boston MA
International Classification:
C12N 5/00, C12N 5/02
US Classification:
435375, 435377
Abstract:
The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E(PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.
Compositions For Promoting Hematopoietic Stem Cell Growth
US Patent:
2013020, Aug 15, 2013
Filed:
Mar 15, 2013
Appl. No.:
13/837265
Inventors:
Children's Medical Center Corporation - , US
The General Hospital Corporation - , US
Wolfram Goessling - Chestnut Hill MA, US
The General Hospital Corporation - , US
Wolfram Goessling - Chestnut Hill MA, US
Assignee:
THE GENERAL HOSPITAL CORPORATION - Boston MA
CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA
CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA
International Classification:
A61K 35/28, A61K 45/06
US Classification:
424 937
Abstract:
The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E(PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.
Methods For Promoting Hematopoietic Reconstitution
US Patent:
2013020, Aug 15, 2013
Filed:
Mar 15, 2013
Appl. No.:
13/836794
Inventors:
Children's Medical Center Corporation - , US
The General Hospital Corporation - , US
Wolfram Goessling - Chestnut Hill MA, US
The General Hospital Corporation - , US
Wolfram Goessling - Chestnut Hill MA, US
Assignee:
THE GENERAL HOSPITAL CORPORATION - Boston MA
CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA
CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA
International Classification:
A61K 35/28, C12N 5/0789
US Classification:
424 937
Abstract:
The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E(PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.
Methods For Promoting Hsc Self-Renewal
US Patent:
2012018, Jul 26, 2012
Filed:
Mar 27, 2012
Appl. No.:
13/431563
Inventors:
Leonard I. Zon - Wellesley MA, US
Trista E. North - Newton Center MA, US
Wolfram Goessling - Chestnut Hill MA, US
Trista E. North - Newton Center MA, US
Wolfram Goessling - Chestnut Hill MA, US
Assignee:
THE GENERAL HOSPITAL CORPORATION - Boston MA
CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA
CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA
International Classification:
A61K 35/12, A61P 7/06, A61P 35/02, A61P 35/00
US Classification:
424 937
Abstract:
The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E(PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.
Method To Modulate Hematopoietic Stem Cell Growth
US Patent:
2011020, Aug 25, 2011
Filed:
May 28, 2009
Appl. No.:
12/994527
Inventors:
Leonard I. Zon - Wellesley MA, US
Trista E. North - Newton Center MA, US
Wolfram Goessling - West Roxbury MA, US
Trista E. North - Newton Center MA, US
Wolfram Goessling - West Roxbury MA, US
International Classification:
A61K 33/00, C12N 5/0789, A61K 31/197, A61K 31/517, A61K 31/138, A61K 31/4418, A61K 31/7048, A61K 31/198, A61K 31/295, A61K 31/165, A61K 31/4985, A61K 31/137, A61K 31/44, A61K 31/353, A61K 31/216, A61P 7/00
US Classification:
424718, 435377, 514562, 51425217, 514652, 514356, 514 26, 514565, 514502, 514620, 514250, 514653, 514352, 514456, 514654, 514532, 514655
Abstract:
Described herein are methods, compositions and kits related to manipulating hematopoietic stem cells (HSC) and more particularly to methods, compositions and kits related to increasing the number of hematopoietic stem cells in vitro, ex vivo and/or in vivo. Also described are methods, compositions and kits related to making an expanded population of HSC and methods, compositions and kits related to using the expanded population of HSC. For example, HSC growth may be enhanced by contacting the nascent stem cells or HSC with an agent that stimulates the nitric oxide signaling pathway.