Inventors:
KENNETH CHIEN - LA JOLLA CA, US
WOLFGANG DILLMAN - LA JOLLA CA, US
SUSUMU MINAMISAWA - LA JOLLA CA, US
HUAPING HE - LA JOLLA CA, US
MASAHIKO HOSHIJIMA - LA JOLLA CA, US
MARKUS MEYER - LA JOLLA CA, US
CHRISTOPHER SCOTT - SAN DIEGO CA, US
YIBIN WANG - LA JOLLA CA, US
GREGG J. SILVERMAN - LA JOLLA CA, US
International Classification:
A61K 31/7088, A61P 9/00
Abstract:
The present invention provides a method for the treatment of heart failure through the use of small peptide complexes and recombinant proteins which function to enhance contractility in failing hearts and reduce blood pressure in individuals with hypertension by inhibiting the interaction between phospholamban and sacroplasmic reticulum Ca ATPase (SERCA2a) within cardiomyocytes. In addition, a means is provided for the transport of such therapeutic agents into the cytoplasm and nucleus of cardiomyocytes.