Inventors:
Surendra A. Sangekar - Union NJ
Winston A. Vadino - Whitehouse Station NJ
Ping I. Lee - Radnor PA
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
A61K 31495, A61K 31675, A61K 3154, A61K 31535
Abstract:
A pharmaceutical composition comprising:
i) substantially inert beads; wherein said beads are coated with
ii) an antifungal agent which is (-)-(2R-cis)-4-�4-�4-�4-��-5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-tr iazol-1-ylmethyl)furan-3-yl!methoxy!phenyl!-1-piperazinyl!phenyl!-2,4-dihyd ro-2-�(S)-1-ethyl-2(S)-hydroxypropyl!-3H-1,2,4-triazol-3-one;
iii) a binder to enables the antifungal compound to adhere to said beads.
The composition enables the antifungal compound, which has very low water solubility, to have enhanced bioavailability in mammals, such as humans.