WILLIAM W SCHLAEPFER
Medical Practice in Philadelphia, PA
License number
Pennsylvania MD023185E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Philadelphia, PA 19103
Personal information
See more information about WILLIAM W SCHLAEPFER at radaris.comName
Address
Phone
3400 Spruce St, Philadelphia, PA 19104
2027 Chancellor St, Philadelphia, PA 19103
Professional information
Methods And Transgenic Mouse Model For Identifying And Modulating Factors Leading To Motor Neuron Degeneration
US Patent:
2002015, Oct 17, 2002
Filed:
Nov 27, 2001
Appl. No.:
09/994420
Inventors:
William Schlaepfer - Philadelphia PA, US
International Classification:
A01K067/027, C12Q001/68
US Classification:
800/018000, 435/006000
Abstract:
Methods are provided for identifying factors involved in motor neuron degeneration by identifying factors affected by alterations in a C-binding complex of a ribonucleotide protein complex, isolating and purifying the factors or nucleic acid sequences; and examining the neuropathic effect of the factors or nucleic acid sequences encoding the factors in a transgenic mouse. Also provided is a transgenic mouse model which expresses a mutant transgenic NF mRNA and exhibits degeneration of motor neurons. This model can be used to test, screen and identify factors and nucleic acid sequences encoding factors causing degeneration of motor neurons.
Methods And Transgenic Mouse Model For Identifying And Modulating Factors Leading To Motor Neuron Degeneration
US Patent:
6323391, Nov 27, 2001
Filed:
Jan 21, 2000
Appl. No.:
9/489979
Inventors:
William W. Schlaepfer - Philadelphia PA
Assignee:
Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
A01K 67027, G01N 3300
US Classification:
800 18
Abstract:
Methods are provided for identifying factors involved in motor neuron degeneration by identifying factors affected by alterations in a C-binding complex of a ribonucleotide protein complex, isolating and purifying the factors or nucleic acid sequences; and examining the neuropathic effect of the factors or nucleic acid sequences encoding the factors in a transgenic mouse. Also provided is a transgenic mouse model which expresses a mutant transgenic NF mRNA and exhibits degeneration of motor neurons. This model can be used to test, screen and identify factors and nucleic acid sequences encoding factors causing degeneration of motor neurons.
Dr. William W Schlaepfer, Philadelphia PA - MD (Doctor of Medicine)
Specialties:
Neuropathology
Address:
3400 Spruce St SUITE 6, Philadelphia 19104
(215) 662-6503 (Phone), (215) 349-5910 (Fax)
(215) 662-6503 (Phone), (215) 349-5910 (Fax)
Certifications:
Anatomic Pathology, 1964, Neuropathology, 1964
Awards:
Healthgrades Honor Roll
Languages:
English
Hospitals:
3400 Spruce St SUITE 6, Philadelphia 19104
Hospital of the University of Pennsylvania
3400 Spruce St, Philadelphia 19104
Hospital of the University of Pennsylvania
3400 Spruce St, Philadelphia 19104
Education:
Medical School
Yale University
Graduated: 1958
Grace-New Haven Community Hospital
Yale University
Graduated: 1958
Grace-New Haven Community Hospital
Professor At Upenn Med School
Position:
professor at UPENN Med School
Location:
Greater Philadelphia Area
Industry:
Medical Practice
Work:
UPENN Med School
-
professor
William Schlaepfer, Philadelphia PA
Work:
Hospital of the University of PA
3400 Spruce St, Philadelphia, PA 19175
3400 Spruce St, Philadelphia, PA 19175
Compositions And Methods For Inhibiting Motor Neuron Degeneration
US Patent:
2002014, Oct 3, 2002
Filed:
Feb 21, 2002
Appl. No.:
10/082032
Inventors:
William Schlaepfer - Philadelphia PA, US
International Classification:
C12Q001/68, C12N009/64
US Classification:
435/006000, 435/226000
Abstract:
An RNA neuropathic element is provided that is produces motor neuron degeneration in animals. Methods are provided for identifying components of RNA-protein complexes that can prevent motor neuron degeneration.