WILLIAM THOMAS HORNE
Real Estate Commission in Pittsburgh, PA
License number
Pennsylvania RS163367A
Category
Real Estate Commission
Type
Real Estate Salesperson-Standard
Address
Address
Pittsburgh, PA 15214
Professional information
Method Of Making Biologically Active Alpha-Beta Peptides
US Patent:
8642536, Feb 4, 2014
Filed:
Oct 14, 2009
Appl. No.:
12/578993
Inventors:
William S. Horne - Pittsburgh PA, US
Samuel H. Gellman - Madison WI, US
Lisa M. Johnson - Marshall MN, US
Samuel H. Gellman - Madison WI, US
Lisa M. Johnson - Marshall MN, US
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
A01N 37/18, A61K 38/55, A61P 31/18, C12N 5/071, A61K 38/00, C07K 5/00, C07K 7/00, C07K 16/00, C07K 17/00, A61K 38/04
US Classification:
514 41, 435366, 530324, 530325, 530326, 530333
Abstract:
Described is a method of fabricating biologically active, unnatural polypeptides. The method includes the steps of selecting a biologically active polypeptide or biologically active fragment thereof having an amino acid sequence comprising α-amino acid residues, and fabricating a synthetic polypeptide that has an amino acid sequence that corresponds to the sequence of the biologically active polypeptide, but wherein about 14% to about 50% of the α-amino acid residues found in the biologically active polypeptide or fragment of step (a) are replaced with β-amino acid residues, and the α-amino acid residues are distributed in a repeating pattern.