DR. WILLIAM T PHILLIPS, MD
Medical Practice at Floyd Curl Dr, San Antonio, TX

5940880, Aug 24, 1999

Dec 12, 1997

8/989495

William T. Phillips - San Antonio TX

Bio Targeting, Inc. - San Antonio TX

A42B 300, A45F 320, B67D 554

2 7

A flexible water container carried on the back of the user in a position that does not restrict the active movement of the user during exercise. Connected to the water container is a tube to conduct the water from the container to an irrigation system positioned within a helmet or otherwise placed about the head of the user. A pressurized air bladder is positioned adjacent to the water container in a manner such that pressure within the air bladder has a tendency to force water from the water container into the tube and thus into the irrigation system. The air bladder is inflatable by means a hand pump connected to the bladder through a flexible tube. The irrigation system is constructed and configured so as to appropriately surround the head of the user and further includes a soft, flexible wick material worn about the head for the purpose of conducting water forced from the irrigation system evenly about the user's head.

5122362, Jun 16, 1992

Dec 4, 1989

7/445884

William T. Phillips - San Antonio TX
Joyce G. Schwartz - San Antonio TX

Board of Regents, The University of Texas System - Austin TX

G01N 3100

424 9

The present invention provides methods and compositions for measuring glucose tolerance in a subject. The methods are useful in a variety of contexts, such as in the diagnosis of diabetes in both human and animal subjects, in assessing gastric emptying times, and even in the diagnosis of insulin resistance. It is proposed that the methods of the present invention will prove to be of particular use in the mass screenings of population, e. g. , in screening for type II diabetes mellitus, due to its simplicity and reproducibility. The method is even adaptable to simple finger stick analysis. The invention method includes the use of a potable beverage containing a low total loading dose of glucose in a low osmolar solution. The oral glucose solutions of the present invention empty rapidly from the stomach, thereby eliminating the nausea and vomiting typically associated with oral glucose tolerance tests. The oral glucose solutions of the present invention provide a provide excellent reproducibility of results and a distinct separation between nondiabetic and diabetic subjects, thereby enabling clinicians to better diagnose diabetes in a subject.

5468727, Nov 21, 1995

Feb 16, 1993

8/019159

William T. Phillips - San Antonio TX
Joyce G. Schwartz - San Antonio TX
Gary M. Green - San Antonio TX

Board of Regents, The University of Texas System

C07K 1400, A61K 3816

514 12

The invention relates to a method of diagnosing and treating individuals with diabetes or at risk to develop diabetes mellitus. In particular, gastric emptying determinations are used to assess risk. Risk or early symptoms associated with subsequent development of diabetes mellitus may be controlled or alleviated by delaying gastric emptying. Delay or inhibition of gastric emptying is sufficient to restore gastric emptying within normal ranges as determined by restoration of typical glucose metabolic parameters such as blood glucose and insulin levels to normal or near normal ranges. The method is also useful in prophylactic treatment of individuals at high risk to develop diabetes mellitus, such as the obese, those with a family history of diabetes and those of particular ethnic and minority groups.

5187154, Feb 16, 1993

Dec 13, 1990

7/626579

William Phillips - San Antonio TX
Joyce G. Schwartz - San Antonio TX

Board of Regents, The University of Texas System - Austin TX

A61K 3700, A61K 4900

514 12

The invention relates to a method of diagnosing and treating individuals with diabetes or at risk to develop diabetes mellitus. In particular, gastric emptying determinations are used to assess risk. Risk or early symptoms associated with subsequent development of diabetes mellitus may be controlled or alleviated by delaying gastric emptying. Delay or The Government may have certain rights in the invention pursuant to grant No. 2-S07-RR07187-11.

5143713, Sep 1, 1992

Nov 5, 1990

7/610204

William T. Phillips - San Antonio TX
Robert W. Klipper - San Antonio TX
James H. Timmons - Tacoma WA
Alan S. Rudolph - Bowie MD

Board of Regents, The University of Texas System - Austin TX
The United States of America as represented by the Secretary of the Navy - Washington DC

A61K 4300, A61K 4902, A61K 9127

424 11

The invention relates to the efficient preparation of radionuclide labeled liposomes and radionuclide-labeled liposome-encapsulated protein. In particular, a. sup. 99m Tc carrier is used to label preformed liposomes or liposome-encapsulated hemoglobin. . sup. 99m Tc-labeled liposomes and liposome-encapsulated. sup. 99m Tc labeled hemoglobin are highly stable in vitro and in vivo and are suitable for a variety of clinical uses, including biodistribution imaging studies. The invention also relates to a method of labeling neutrophils using. sup. 99m technetium-labeled liposomes or liposome-encapsulated hemoglobin. A kit method useful for the convenient preparation of. sup. 99m Tc-labeled liposomes or liposome-encapsulated hemoglobin for clinical use is also disclosed.

7718160, May 18, 2010

May 22, 2003

10/518872

Ande Bao - San Antonio TX, US
William T. Phillips - San Antonio TX, US
Beth Goins - San Antonio TX, US

The Board of Regents of the University of Texas System - Austin TX

A61K 51/00, A61M 36/14, C07F 5/00, C07F 13/00

424 165, 424 111, 424 121, 424 161, 534 11, 534 14

The invention, in one aspect, relates to radiolabeled compounds. The invention also relates to radiolabeled liposomes and methods of making and using thereof. The invention also relates to kits for preparing radiolabeled liposomes.

5158760, Oct 27, 1992

May 30, 1990

7/530847

William T. Phillips - San Antonio TX
Robert W. Klipper - San Antonio TX
James H. Timmons - Tacoma WA
Alan S. Rudolph - Bowie MD

Board of Regents, The University of Texas System - Austin TX
The United States of America as represented by the Secretary of the Navy - Washington DC

A61K 4300, A61K 4902, A61K 9127, A61K 9133

424 11

The invention relates to a. sup. 99m Tc-labeled liposome encapsulated protein and to a highly efficient method of radiolabeling liposome encapsulated protein. In particular, a. sup. 99m Tc carrier is used to label preformed liposome-encapsulated hemoglobin. The liposome-encapsulated. sup. 99m Tc labeled hemoglobin is highly stable in vitro and in vivo and is suitable for a variety of clinical uses, including biodistribution imaging studies. The invention also relates to a method of using technetium-. sup. 99m labeled liposome encapsulated hemoglobin to label neutrophils. A kit method which could be used for the convenient preparation of. sup. 99m Tc-labeled liposome encapsulated hemoglobin for clinical use is also disclosed.

4935223, Jun 19, 1990

Aug 4, 1988

7/229069

William Phillips - San Antonio TX

Board of Regents, The University of Texas System - Austin TX

A61K 4902, A61K 4900

424 11

A process is provided for the labeling of viable eucaryotic cells. The process includes the steps of collecting, separating, and introducing a quantity of first type cells into a non-toxic media suitable to conduct an electric field. A labeling material is added to this media. The media containing the first type cells and the labeling material is pulsed for a period of time with an electric field, sufficient to render the cell membranes permeable so that the labeling material permeates the cells and becomes trapped therein upon cessation of the pulsing to produce labeled cells. Also provided is a process for diagnostically imaging pathological sites in a patient. This process contains the additional steps of administering the labeled cells to a patient and monitoring the localization of the labeling material in the patient to image the locus of a specific pathosis.