DR. WILLIAM SHUFORD SLY, MD
Osteopathic Medicine in Saint Louis, MO
License number
Missouri 26759
Category
Osteopathic Medicine
Type
General Practice
Address
Address
1100 Drc Rm 433 St, Saint Louis, MO 63104
Phone
(314) 977-9229
(314) 977-9206 (Fax)
(314) 862-5860 (Fax)
(314) 977-9206 (Fax)
(314) 862-5860 (Fax)
Personal information
See more information about WILLIAM SHUFORD SLY at radaris.comName
Address
Phone
7054 Westmoreland Dr, Saint Louis, MO 63130
611 Lazy Days Rd, Osage Beach, MO 65065
7054 Westmoreland Dr, Saint Louis, MO 63130
Columbia, MO
Professional information
See more information about WILLIAM SHUFORD SLY at trustoria.com
Dr. William S Sly, Saint Louis MO - MD (Doctor of Medicine)
Dr. William S Sly, Saint Louis MO - MD (Doctor of Medicine)
Specialties:
Other
Address:
1100 S Grand Blvd, Saint Louis 63104
(314) 977-9229 (Phone), (314) 977-9206 (Fax)
(314) 977-9229 (Phone), (314) 977-9206 (Fax)
Languages:
English
Education:
Medical School
Saint Louis University / School of Medicine
Graduated: 1957
Saint Louis University / School of Medicine
Graduated: 1957
Compositions And Methods For Treating Hypophosphatasia
Compositions And Methods For Treating Hypophosphatasia
US Patent:
2011025, Oct 13, 2011
Filed:
Mar 24, 2011
Appl. No.:
13/071445
Inventors:
Shunji Tomatsu - Saint Louis MO, US
William Sly - Saint Louis MO, US
Jeffrey Grubb - Saint Louis MO, US
Tatsuo Nishioka - Kanazawa, JP
Ken-ichi Miyamoto - Kanazawa, JP
Seiji Yamaguchi - Izumo, JP
William Sly - Saint Louis MO, US
Jeffrey Grubb - Saint Louis MO, US
Tatsuo Nishioka - Kanazawa, JP
Ken-ichi Miyamoto - Kanazawa, JP
Seiji Yamaguchi - Izumo, JP
Assignee:
Saint Louis University - Saint Louis MO
International Classification:
A61K 35/54, A61P 3/00, A61K 48/00, C12N 9/16, A61K 38/46
US Classification:
424 9321, 435196, 424 946, 514 44 R
Abstract:
The present invention provides compositions and methods for use in enzyme replacement therapy. The inventors disclose a method of producing membrane bound enzymes in an active soluble form by eliminating the glycosylphosphatidylinositol (GPI) membrane anchor. In particular the inventors disclose a soluble active form of the membrane bound enzyme TNSALP which they produced by deleting the GPI anchor single peptide sequence. They have further shown that this composition is useful for treatment of hypophosphatasia. The inventors also disclose oligo acid amino acid variants thereof which specifically target bone tissue.
Compositions And Methods For Treating Hypophosphatasia
Compositions And Methods For Treating Hypophosphatasia
US Patent:
7943126, May 17, 2011
Filed:
Mar 17, 2009
Appl. No.:
12/405920
Inventors:
Shunji Tomatsu - Saint Louis MO, US
William S Sly - Saint Louis MO, US
Jeffrey H Grubb - Saint Louis MO, US
Tatsuo Nishioka - Kanazawa, JP
Ken-ichi Miyamoto - Kanazawa, JP
Seiji Yamaguchi - Izumo, JP
William S Sly - Saint Louis MO, US
Jeffrey H Grubb - Saint Louis MO, US
Tatsuo Nishioka - Kanazawa, JP
Ken-ichi Miyamoto - Kanazawa, JP
Seiji Yamaguchi - Izumo, JP
Assignee:
Saint Louis University - Saint Louis MO
International Classification:
A61K 38/43, A61P 19/08, C12N 9/00, C12P 21/02
US Classification:
424 941, 514 12, 530350, 435 691, 435183
Abstract:
The present invention provides compositions and methods for use in enzyme replacement therapy. The inventors disclose a method of producing membrane bound enzymes in an active soluble form by eliminating the glycosylphosphatidylinositol (GPI) membrane anchor. In particular the inventors disclose a soluble active form of the membrane bound enzyme TNSALP which they produced by deleting the GPI anchor single peptide sequence. They have further shown that this composition is useful for treatment of hypophosphatasia. The inventors also disclose oligo acid amino acid variants thereof which specifically target bone tissue.