Inventors:
Gyanu Lamichhane - Towson MD, US
William R. Bishai - Towson MD, US
Radhika Gupta - Uttar Pradesh, IN
Marie Lavollay - Bourg La Reine, FR
Jean-Luc Mainardi - Chaville, FR
Michel Arthur - Arcueil, FR
Assignee:
CENTRE DE RECHERCHE DES CORDELIERS - PARIS
THE JOHNS HOPKINS UNIVERSITY - BALTIMORE MD
International Classification:
A61K 31/43, A61K 31/424, A61P 31/04, A61K 31/407
US Classification:
514197, 5142101, 51421013, 51421006
Abstract:
The peptidoglycan layer is a vital component of the bacterial cell wall, which comprises 4→3 and 3→3 transpeptide cross-linkages, the formation of which are catalyzed by D,D- and L,D-transpeptidases, respectively. Methods for the treatment of bacterial infections with agents that inhibit L,D-transpeptidases, either alone or in combination with D,D-transpeptidase inhibitors, are provided herein. Also provided are methods for the treatment of chronic stage tuberculosis with agents that inhibit enzyme with L,D-transpeptidase activity.