DR. WILLIAM RAFAEL ROBERTS, O.D.
Optometry at 64 St, Gainesville, FL

6740646, May 25, 2004

Jan 16, 2002

10/053345

William J. Roberts - Gainesville FL

Biotest Laboratories, LLC - Colorado Springs CO

A61K 31568

514178, 514182, 552633

A compound is provided for increasing the concentration of a parent androgen in a subject in vivo. The parent androgen has a skeletal structure including a 1 position and a 17 position, a 17-hydroxy group comprising a 17-hydroxy oxygen appended to the 17 position, and a 17-hydroxy hydrogen appended to the 17-hydroxy oxygen. The compound includes a substrate having the skeletal structure of the parent androgen. It includes a 1 position and a 17 position corresponding to the 1 and 17 positions respectively of the parent androgen. The substrate has a carbon—carbon double bond at the 1 position. The compound also has a promoiety appended to the 17-hydroxy oxygen of the substrate as a substitute for the 17-hydroxy hydrogen of the parent androgen. The promoiety includes, and preferably consists of, an alkylcarbonate ester. A related method also is provided.

6818668, Nov 16, 2004

Apr 12, 2002

10/123068

William J. Roberts - Gainesville FL

Biotest Laboratories, LLC - Colorado Springs CO

A61K 3135

514456, 514457, 549402, 549403

A compound is provided for increasing the concentration of a parent isoflavone in a subject in vivo. The parent isoflavone has a skeletal structure including a 5 position and a 7 position, a 5 alkyl group, and a 7-hydroxy group with a 7-hydroxy oxygen appended to the 7 position and a 7-hydroxy hydrogen appended to the 7-hydroxy oxygen. The compound includes a substrate having the skeletal structure of the parent isoflavone, with a 5 position and a 7 position corresponding to the 5 and 7 positions respectively of the parent isoflavone. An alkyl group is appended to the 5 position. A promoiety is appended to the 7-hydroxy oxygen of the substrate as a substitute for the 7-hydroxy hydrogen of the parent isoflavone, the promoiety and the 7-hydroxy oxygen establishing an alkylcarbonate ester. A related method also is provided.

2003013, Jul 17, 2003

Oct 3, 2002

10/265218

William Roberts - Gainesville FL, US

A61K031/573

514/170000

A composition is provided including a first prohormone for increasing the concentration of a Class I parent androgen in a subject in vivo, and a second prohormone for increasing the concentration of a Class II parent androgen in the subject in vivo. The first prohormone includes a first carbon-carbon double bond at the 1 position, and a first 17-hydroxy oxygen appended to the 17 position. The first prohormone further includes a first 17-position promoiety is appended to the first 17-hydroxy oxygen as a substitute for the 17-hydroxy hydrogen of the Class I parent androgen. The second prohormone includes a second carbon-carbon double bond at the 4 position and a second 17-hydroxy oxygen appended to the 17 position. The second prohormone also includes a second 17-position promoiety appended to the second 17-hydroxy oxygen as a substitute for the 17-hydroxy hydrogen of the Class II parent androgen.

2003013, Jul 17, 2003

Jan 16, 2002

10/053505

William Roberts - Gainesville FL, US

A61K031/57, C07J001/00

514/178000, 552/639000

A compound is provided for increasing the concentration of a parent androgen in a subject in vivo. The parent androgen has a skeletal structure including a 4 position and a 17 position. It has a 17-hydroxy group that includes a 17-hydroxy oxygen appended to the 17 position and a 17-hydroxy hydrogen appended to the 17-hydroxy oxygen. The compound includes a substrate having the skeletal structure of the parent androgen, wherein the substrate includes a 4 position and a 17 position corresponding to the 4 and 17 positions respectively of the parent androgen. The substrate according to one aspect of the invention includes a carbon-carbon double bond at the 4 position. The skeletal structure of the parent androgen embodied in the substrate being selected from the group consisting of androst-4-ene-3,17-diol, androst-4-ene-3,17-diol, and mixtures thereof, or estr-4-ene-3,17-diol, estr-4-ene-3,17-diol, and mixtures thereof, or combinations of these. A promoiety is appended to the 17-hydroxy oxygen of the substrate as a substitute for the hydroxy hydrogen of the parent androgen. The promoiety constitutes or includes an alkylcarbonate ester. Related methods are included as well.

2005011, May 26, 2005

May 25, 2004

10/854028

William Roberts - Gainesville FL, US

A61K031/56

514182000

A compound is provided for increasing the concentration of a parent androgen in a subject in vivo. The parent androgen has a skeletal structure including a 1 position and a 17 position, a 17β-hydroxy group comprising a 17β-hydroxy oxygen appended to the 17 position, and a 17β-hydroxy hydrogen appended to the 17β-hydroxy oxygen. The compound includes a substrate having the skeletal structure of the parent androgen. It includes a 1 position and a 17 position corresponding to the 1 and 17 positions respectively of the parent androgen. The substrate has a carbon-carbon double bond at the 1 position. The compound also has a promoiety appended to the 17β-hydroxy oxygen of the substrate as a substitute for the 17β-hydroxy hydrogen of the parent androgen. The promoiety includes, and preferably consists of, an alkylcarbonate ester. A related method also is provided.

7625943, Dec 1, 2009

Jun 14, 2004

10/868164

William J. Roberts - Gainesville FL, US

A61K 31/352

514456

A compound is provided for increasing the concentration of a parent isoflavone in a subject in vivo. The parent isoflavone has a skeletal structure including a 5 position and a 7 position, a 5 alkyl group, and a 7-hydroxy group with a 7-hydroxy oxygen appended to the 7 position and a 7-hydroxy hydrogen appended to the 7-hydroxy oxygen. The compound includes a substrate having the skeletal structure of the parent isoflavone, with a 5 position and a 7 position corresponding to the 5 and 7 positions respectively of the parent isoflavone. An alkyl group is appended to the 5 position. A promoiety is appended to the 7-hydroxy oxygen of the substrate as a substitute for the 7-hydroxy hydrogen of the parent isoflavone the promoiety and the 7-hydroxy oxygen establishing an alkylcarbonate ester. A related method also is provided.

2002018, Dec 5, 2002

Jun 1, 2001

09/872705

William Roberts - Gainesville FL, US

C07J003/00, A61K031/56, C07J001/00

552/611000, 552/638000, 514/178000

A compound for supplementing the concentration of a parent androgen in a subject in vivo, wherein the parent androgen has a skeletal structure including a 17 position and the parent androgen further has a 17-hydroxy group comprising a 17-hydroxy hydrogen appended to the 17 position. The compound comprises a substrate having the skeletal structure of the parent androgen including a 17 position corresponding to the 17 position of the parent androgen, and a promoiety comprising an alkoxymethyl ether appended to the 17 position of the substrate as a substitute for the 17-hydroxy hydrogen. Related compounds and methods also are disclosed.