WILLIAM R HENDERSON
Osteopathic Medicine at Pacific St, Seattle, WA

2009017, Jul 9, 2009

Sep 25, 2007

11/861009

William R. HENDERSON - Seattle WA, US
Michael KAHN - Altadena CA, US

UNIVERSITY OF WASHINGTON - Seattle WA
INSTITUTE FOR CHEMICAL GENOMICS - Kirkland WA

A61K 31/4985, A61K 31/675, A61K 31/538, A61K 31/53

514 81, 514249, 5142305, 514243

The invention provides α-mimetic structure of formula (I), wherein A is —(C═O)—(CHR)— or —(C═O)—; B is —(NR)— or —(CHR)—; D is —(C═O)—(CHR)— or —(C═O)—; E is -(ZR)— or —(C═O)—, where Z is nitrogen or CH; —(XR)—, —(CHR)—(NR)—, —(C═O)—(XR)—, —(C═N—W—R)—, —(C═O)—, —(X—(C═O)—R)—, —(X—(C═O)—NRR)—, —(X—(SO)—R)—, or —(X—(C═O)—OR)—, where X is nitrogen or CH, and n=0 or 1; W is —Y(C═O)—, —(C═O)—(NH)—, —(SO)—, —(CHR)—, —(C═O)—(NR)—, substituted or unsubstituted oxadiazole, substituted or unsubstituted triazole, substituted or unsubstituted thiadiazole, substituted or unsubstituted 4,5-dihydrooxazole, substituted or unsubstituted 4,5-dihydrothiazole, substituted or unsubstituted 4,5-dihydroimidizole, or nothing, where Y is oxygen or sulfur; and R, R, R, R, R, R, R, R, RR, R, R, R, R, and Rare the same or different and independently selected from an amino acid side chain moiety or derivative thereof, the remainder of the molecule, a linker and a solid support, and stereoisomers, salts, and prodrugs thereof, provided that where B is —(CHR) and W is —Y(C═O)—, —(C═O)—(NH)—, —(SO)—, —(CHR)—, or —(C═O)—(N)—, G cannot be —(CHR)—, —(NR)—, —(C═O)—(CHR)—, —(C═O)—(NR)—, or no atom at all. Additionally, the invention provides methods wherein α-mimetic compounds are used to treat a disease or pathological condition.

2008024, Oct 2, 2008

Sep 25, 2007

11/861072

William R. HENDERSON - Seattle WA, US
Emil Y. CHI - Seattle WA, US
Michael KAHN - Altadena CA, US

UNIVERSITY OF WASHINGTON - Seattle WA
INSTITUTE FOR CHEMICAL GENOMICS - Kirkland WA

A61K 31/4985, A61P 25/28, A61P 17/02, A61P 27/06, A61P 13/12

514249

The invention provides α-mimetic structure of formula (I), wherein A is —(C═O)—(CHR)— or —(C═O)—; B is —(NR)— or —(CHR)—; D is —(C═O)—(CHR)— or —(C═O)—; E is -(ZR)— or —(C═O)—, where Z is nitrogen or CH; —(XR)—, —(CHR)—(NR)—, —(C═O)—(XR)—, —(C═N—W—R)—, —(C═O)—, —(X—(C═O)—R)—, —(X—(C═O)—NRR)—, —(X—(SO)—R)—, or —(X—(C═O)—OR)—, where X is nitrogen or CH, and n=0 or 1; W is —Y(C═O)—, —(C═O)—(NH)—, —(SO)—, —(CHR)—, —(C═O)—(NR)—, substituted or unsubstituted oxadiazole, substituted or unsubstituted triazole, substituted or unsubstituted thiadiazole, substituted or unsubstituted 4,5-dihydrooxazole, substituted or unsubstituted 4,5-dihydrothiazole, substituted or unsubstituted 4,5-dihydroimidazole, or nothing, where Y is oxygen or sulfur; and R, R, R, R, R, R, R, R, RR, R, R, R, R, and Rare the same or different and independently selected from an amino acid side chain moiety or derivative thereof, the remainder of the molecule, a linker and a solid support, and stereoisomers, salts, and prodrugs thereof, provided that where B is —(CHR) and W is —Y(C═O)—, —(C═O)—(NH)—, —(SO)—, —(CHR)—, or —(C═O)—(NR), G cannot be —(CHR)—, —(NR)—, —(C═O)—(CHR)—, —(C═O)—(NR)—, or no atom at all. Additionally, the invention provides methods wherein α-mimetic compounds are used to reverse fibrotic conditions.

2008015, Jun 26, 2008

Sep 25, 2007

11/860933

William R. HENDERSON - Seattle WA, US
Emil Y. Chi - Seattle WA, US
Michael Kahn - Kirkland WA, US

UNIVERSITY OF WASHINGTON - Seattle WA
INSTITUTE FOR CHEMICAL GENOMICS - Kirkland WA

A61K 38/12, A61P 3/00, A61P 11/00, A61P 19/00, A61P 17/00

514 10

The invention provides α-helix mimetic structures of formula (I) with the definitions of A, B, D, E, G, W, Rand Ras set out in the description and a chemical library relating thereto. The compounds, pharmaceutical compositions comprising the compounds, and methods of the invention using the compounds, relate to the reversal of fibrotic conditions, such as pulmonary fibrosis.

2008017, Jul 17, 2008

Sep 25, 2007

11/860912

William R. HENDERSON - Seattle WA, US
Michael KAHN - Altadena CA, US

UNIVERSITY OF WASHINGTON - Seattle WA
INSTITUTE FOR CHEMICAL GENOMICS - Kirkland WA

A61K 31/53, A61K 31/4985, A61P 11/00, A61P 17/00

514243, 514249

The invention provides α-helix mimetic structures of formula (I) with the definitions of A, B, D, E, G, W, Rand Ras set out in the description and a chemical library relating thereto. The compounds, pharmaceutical compositions comprising the compounds, and methods of the invention using the compounds, relate to the treatment of fibrotic diseases, such as pulmonary fibrosis.