WILLIAM R BACHMAN
Pharmacy in New Brunswick, NJ
License number
Pennsylvania RP033470L
Category
Pharmacy
Type
Pharmacist
Address
Address
2
New Brunswick, NJ 08902
Pennsylvania
Pennsylvania
Personal information
See more information about WILLIAM R BACHMAN at radaris.comName
Address
Phone
513 Hamilton Dr, Hackettstown, NJ 07840
519 Schwabe St, Freeland, PA 18224
456 Chestnut St, Columbia, PA 17512
4430 Aldine St, Philadelphia, PA 19136
425 Nazareth Dr, Nazareth, PA 18064
Professional information
Pharmaceutical Compositions In The Form Of Beadlets And Method
US Patent:
4808413, Feb 28, 1989
Filed:
Dec 31, 1987
Appl. No.:
7/140281
Inventors:
Yatindra M. Joshi - Piscataway NJ
William R. Bachman - North Brunswick NJ
Nemichand B. Jain - Monmouth Junction NJ
William R. Bachman - North Brunswick NJ
Nemichand B. Jain - Monmouth Junction NJ
Assignee:
E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:
A61K 914, A61K 926, A61K 952
US Classification:
424458
Abstract:
A pharmaceutical composition is provided which is in the form of a plurality of beadlets, adapted to be filled into pharmaceutical hard shell capsules, or compressed into tablets, which beadlets are formed of a pharmaceutical such as an ACE inhibitor, for example, captopril, a beta-blocker such as nadolol, propranolol or atenolol, a calcium channel blocker such as diltiazem or nifedipine or other pharmaceuticals including combinations thereof, binder such as microcrystalline cellulose, and at least 5% by weight of an acid processing aid, such as citric acid, which imparts plasticity to the wet mass needed for efficient extrusion and spheronization. A method for forming beadlets is also provided which includes the steps of extruding a composition as described above, and subjecting the resulting extrudate to a spheronization step wherein an acid processing aid such as citric acid is employed to improve processing and form improved beadlets.