WILLIAM MITCHELL PARKER, PA
Nursing at Montgomery Hwy, Birmingham, AL
License number
Alabama PA116
Category
Nursing
Type
Surgical
Address
Address
200 Montgomery Hwy SUITE 200, Birmingham, AL 35216
Phone
(205) 822-9595
Personal information
See more information about WILLIAM MITCHELL PARKER at radaris.comName
Address
Phone
511 Manvail Ct, Saraland, AL 36571
529 Cedar Creek Rd, Luverne, AL 36049
521 County Road 521, Moulton, AL 35650
5188 Crowley Dr, Birmingham, AL 35210
107 Liberty St S, Clanton, AL 35045
Professional information
Purine Nucleoside Phosphorylase Gene Therapy For Human Malignancy
US Patent:
5552311, Sep 3, 1996
Filed:
Sep 14, 1993
Appl. No.:
8/122321
Inventors:
Eric J. Sorscher - Birmingham AL
William B. Parker - Birmingham AL
Leonard L. Bennett - Birmingham AL
William B. Parker - Birmingham AL
Leonard L. Bennett - Birmingham AL
Assignee:
University of Alabama at Birmingham Research Foundation - Birmingham AL
Southern Research Inst. - Birmingham AL
Southern Research Inst. - Birmingham AL
International Classification:
C12N 500, C12N 1500
US Classification:
4352402
Abstract:
The invention provides a method of killing replicating or non-replicating, transfected or transduced mammalian cells and bystander cells, comprising the following steps: (a) transfecting or transducing mammalian cells with a nucleic acid encoding a non-human purine nucleoside phosphorylase (PNP); and (b) contacting the transfected or transduced cells with an amount of a substrate for the purine nucleoside phosphorylase sufficient to produce a toxic purine base-analog thereby killing the transfected or transduced cells and bystander cells. In the present method of killing cells, the non-human purine nucleoside phosphorylase can be an E. coli purine nucleoside phosphorylase. The method of the invention described above can utilize a substrate that is a purine nucleoside analog. For instance, in the method provided in the Examples, the substrate is 9-(. beta. -D-2-deoxyerythropentofuranosyl)-6-methylpurine (MeP-dR).
Purine Nucleoside Phosphorylase Gene Therapy For Human Malignancy
US Patent:
6017896, Jan 25, 2000
Filed:
Jun 24, 1997
Appl. No.:
8/881772
Inventors:
Eric J. Sorscher - Birmingham AL
Leonard L. Bennett - Birmingham AL
William B. Parker - Birmingham AL
Leonard L. Bennett - Birmingham AL
William B. Parker - Birmingham AL
Assignee:
University of Alabama Research Foundation and Southern Research Institute - Birmingham AL
International Classification:
A61K 4800, C12N 1500
US Classification:
514 44
Abstract:
The present invention provides a method of killing replicating or non-replicating, transfected or transduced mammalian cells and bystander cells, comprising: (a) transfecting or transducing mammalian cells with a nucleic acid encoding a non-human purine cleavage enzyme; and (b) contacting the transfected or transduced cells with an effective amount of a substrate for the purine cleavage enzyme, wherein the substrate is non-toxic to mammalian cells and is cleaved by the enzyme to yield a purine toxic to the targeted mammalian cells and bystander cells, to kill the mammalian cells expressing the enzyme and the bystander cells. Further provided is a vector comprising a DNA sequence coding for a non-human purine nucleoside phosphorylase protein and the vector is capable of replication and/or expression in a host which comprises, in operable linkage: a) optionally, an origin of replication; b) a promoter; and c) a DNA sequence coding for said protein.
William M Parker, Birmingham AL - PA (Physician assistant; also Posterior–anterior)
Specialties:
Surgical Assistance
Address:
200 Montgomery Hwy SUITE 200, Birmingham 35216
(205) 822-9595 (Phone)
(205) 822-9595 (Phone)
Languages:
English
Recombinant Bacterial Cells For Delivery Of Pnp To Tumor Cells
US Patent:
6491905, Dec 10, 2002
Filed:
Oct 30, 1998
Appl. No.:
09/183188
Inventors:
Eric J. Sorscher - Birmingham AL
William B. Parker - Birmingham AL
William Waud - Mountain Brook AL
Vijayakrishna K. Gadi - Birmingham AL
William B. Parker - Birmingham AL
William Waud - Mountain Brook AL
Vijayakrishna K. Gadi - Birmingham AL
Assignee:
The UAB Research Foundation - Birmingham AL
Southern Research Institute - Birmingham AL
Southern Research Institute - Birmingham AL
International Classification:
C12N 120
US Classification:
424 932, 4352523, 4352527, 435325, 435455, 4353201, 536 232, 536 237, 424 931
Abstract:
The present invention provides a procaryotic host cell stably transformed or transfected by a vector including a DNA sequence encoding for purine nucleoside phosphorylase or hydrolase. The transformed or transfected procaryotic host cell can be used in combination with a purine substrate to treat tumor cells and/or virally infected cells.
William Mitchell Parker, Vestavia AL
Specialties:
Physician Assistant
Address:
200 Montgomery Hwy, Vestavia, AL 35216
Mutant Purine Nucleoside Phosphorylase Proteins And Cellular Delivery Thereof
US Patent:
7037718, May 2, 2006
Filed:
Oct 26, 2001
Appl. No.:
10/035300
Inventors:
Steven E. Ealick - Ithaca NY, US
William B. Parker - Birmingham AL, US
Eric J. Sorscher - Birmingham AL, US
William B. Parker - Birmingham AL, US
Eric J. Sorscher - Birmingham AL, US
Assignee:
Cornell Research Foundation, Inc. - Ithaca NY
Southern Research Institute - Birmingham AL
The UAB Research Foundation - Birmingham AL
Southern Research Institute - Birmingham AL
The UAB Research Foundation - Birmingham AL
International Classification:
C12N 15/85
US Classification:
435325, 4352523, 536 231, 514 44
Abstract:
The present invention provides a procaryotic host cell stably transformed or transfected by a vector including a DNA sequence encoding for mutant purine nucleoside phosphorylase or hydrolase. The transformed or transfected procaryotic host cell can be used in combination with a purine substrate to treat tumor cells and/or virally infected cells. The present invention provides nucleotide sequences encoding mutant derived purine nucleoside phosphorylase proteins which can be used in conjunction with an appropriate substrate to produce toxins which impair abnormal cell growth. The invention provides for delivery of the toxin by generation within target cells or by administration and delivery to the cells from without.
Gene Delivery Compounds
US Patent:
2004020, Oct 14, 2004
Filed:
Nov 3, 2003
Appl. No.:
10/476754
Inventors:
Eric Sorscher - Birmingham AL, US
Jeong Hong - Birmingham AL, US
Jennifer Harris - Birmingham AL, US
Kimberly Curlee - Phoenix AZ, US
Joseph Maddry - Birmingham AL, US
William Parker - Birmingham AL, US
William Wand - Mountain Brook AL, US
Jeong Hong - Birmingham AL, US
Jennifer Harris - Birmingham AL, US
Kimberly Curlee - Phoenix AZ, US
Joseph Maddry - Birmingham AL, US
William Parker - Birmingham AL, US
William Wand - Mountain Brook AL, US
International Classification:
A61K048/00, A61K031/7076, A61K031/15
US Classification:
514/044000, 514/046000, 514/639000
Abstract:
Compounds having the structure:
wherein R, Rand Rare each independently a Csubstituent selected from the group consisting of: hydrogen, a heteroatom, alkyl, alkenyl, alkynyl, heteroatom substituted alkyl, heteroatom substituted alkenyl, heteroatom substituted alkynyl, aryl, arylalkyl, arylalkenyl, arylalkynyl; where the heteroatom is selected from the group consisting of: N, O and S; and where (A) is a single or double bond between N and R. Further the Csubstituent is linear, branched or cyclic and optionally includes a pendant moiety selected from the group consisting of: carbonyl, hydroxyl, carboxyl, amine, thiol, thioester, thioether, phosphate, alkoxy, aryl, arylalkyl, sulfonamide and alkyl halide. Further, compounds 6883, 6898, 6975, 7036, 7064 and 8496 are provided. A process is provided for activating gene transfer in a subject by administering a pharmaceutically effective amount of a gene transfer activating compound to a subject and delivering pharmaceutically effective amount of a vector containing a nucleic so that the nucleic acid is transcribed in a target cell of the subject. A process for activating gene transfer to a cell is provided. A kit for activating gene transfer is provided.
Purine Nucleoside Phosphorylase As Enzymatic Activator Of Nucleoside Prodrugs
US Patent:
8628767, Jan 14, 2014
Filed:
Aug 17, 2009
Appl. No.:
13/059178
Inventors:
William B. Parker - Birmingham AL, US
Eric J. Sorscher - Birmingham AL, US
Eric J. Sorscher - Birmingham AL, US
Assignee:
The UAB Research Foundation - Birmingham AL
Southern Research Institute - Birmingham AL
Southern Research Institute - Birmingham AL
International Classification:
A61K 38/00
US Classification:
424 945, 424 941, 435183
Abstract:
A process for inhibiting a mammalian cancerous cell or virally infected cell includes providing a purine nucleoside phosphorylase enzyme or a tail mutant purine nucleoside phosphorylase enzyme in proximity to the mammalian cancerous cell or the virally infected cell and exposing the enzyme to a purine nucleoside phosphorylase enzyme cleavable substrate to yield a cytotoxic purine analog. The process includes introducing to the cell a vector containing the phosphorylase enzyme, or a DNA sequence coding for the same and delivering to the cell an effective amount of the substrate such as 9-(β-D-arabinofuranosyl)-2-fluoroadenine (F-araA).
Use Of 2'-Deoxy-4'-Thiocytidine And Its Analogues As Dna Hypomethylating Anticancer Agents
US Patent:
2011021, Sep 8, 2011
Filed:
Mar 2, 2010
Appl. No.:
12/715811
Inventors:
Jaideep Thottassery - Birmingham AL, US
Kamal N. Tiwari - Birmingham AL, US
William B. Parker - Birmingham AL, US
Kamal N. Tiwari - Birmingham AL, US
William B. Parker - Birmingham AL, US
Assignee:
Southern Research Institute - Birmingham AL
International Classification:
A61K 31/7068, A61P 35/00
US Classification:
514 49, 514 43
Abstract:
Compounds represented by the formulae:wherein R is individually selected from the group consisting of H, aliphatic acyl, aromatic acyl group, fluoro, chloro, bromo, iodo, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, cyano, aryl and nitro; pharmaceutically acceptable salts thereof, prodrugs thereof, solvates thereof and mixtures thereof; are used as inhibitors of DNA methyltransferase and for treating patients suffering from diseases resulting from or related to aberrant DNA methylation such as myelodysplastic syndromes and other cancers.
Recombinant Bacterial Cells For Delivery Of Pnp To Tumor Cells
US Patent:
2003013, Jul 17, 2003
Filed:
Jul 18, 2002
Appl. No.:
10/198228
Inventors:
Eric Sorscher - Birmingham AL, US
William Parker - Birmingham AL, US
William Waud - Mountain Brook AL, US
Vijayakrishna Gadi - Birmingham AL, US
Leonard Bennett - Birmingham AL, US
William Parker - Birmingham AL, US
William Waud - Mountain Brook AL, US
Vijayakrishna Gadi - Birmingham AL, US
Leonard Bennett - Birmingham AL, US
International Classification:
A61K031/7076, A61K031/522, A61K031/519
US Classification:
514/046000, 514/263300, 514/263370, 514/265100
Abstract:
The present invention provides a procaryotic host cell stably transformed or transfected by a vector including a DNA sequence encoding for purine nucleoside phosphorylase or hydrolase. The transformed or transfected procaryotic host cell can be used in combination with a purine substrate to treat tumor cells and/or virally infected cells.