WILLIAM MING LEE
Medical Practice in Penn Wynne, PA
License number
Pennsylvania MD018490E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Penn Wynne, PA 19096
Personal information
See more information about WILLIAM MING LEE at radaris.comName
Address
Phone
512 Church St, Honesdale, PA 18431
5132 N 9Th St, Philadelphia, PA 19141
506 Brookhurst Ave, Penn Valley, PA 19072
5012 Cypress St, Pittsburgh, PA 15224
504 Linmar Ter, Aliquippa, PA 15001
Professional information
Methods And Compositions For Enhancing The Immunostimulatory Effect Of Interleukin-12
US Patent:
2002008, Jun 27, 2002
Filed:
Feb 20, 2002
Appl. No.:
10/079068
Inventors:
Giorgio Trinchieri - Charly, FR
William Lee - Wynnewood PA, US
Holly Koblish - Yardley PA, US
William Lee - Wynnewood PA, US
Holly Koblish - Yardley PA, US
International Classification:
A61K038/20, A61K031/198, A61K031/21, A61K031/155
US Classification:
424/085200, 514/398000, 514/509000, 514/565000, 514/634000
Abstract:
Methods for enhancing the therapeutic and adjuvant use of IL-by reducing unwanted transient immunosuppression caused by IL-or by high doses thereof involve co-administering IL-with an effective amount of an agent that inhibits or neutralizes nitric oxide (NO) in vivo. Enhanced vaccine therapy involves co-administering the IL-adjuvant, a selected vaccine antigen and the NO inhibiting/neutralizing agent. Additionally, the toxicity of IL-treatment may be reduced by co-administering IL-with an effective amount of the NO inhibiting or neutralizing agent. A therapeutic composition characterized by reduced toxicity in mammals contains IL-preferably a low dose thereof, and an NO inhibiting or neutralizing agent in a pharmaceutically acceptable carrier. A vaccine composition contains an effective adjuvanting amount of IL-an effective amount of an NO inhibiting or neutralizing agent, and an effective protective amount of a vaccine antigen in a pharmaceutically acceptable carrier.
Method And Compositions For Inhibiting Angiogenesis And Treating Cancer With Il-12 And Il-18
US Patent:
2003014, Aug 7, 2003
Filed:
Jan 29, 2003
Appl. No.:
10/353283
Inventors:
Giorgio Trinchieri - Wynnewood PA, US
William Lee - Wynnewood PA, US
Christina Coughlin - Philadelphia PA, US
William Lee - Wynnewood PA, US
Christina Coughlin - Philadelphia PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
A61K048/00
US Classification:
424/093210
Abstract:
A composition useful for preventing, or retarding the growth of, tumor cells contains synergistic amounts of Interleukin-12 and Interleukin-18. Similarly, methods for treating or preventing cancer include co-administering synergistic amounts of IL-12 and IL-18. The resulting anti-tumor effect is greater than the additive effect of either cytokine administered alone.