Inventors:
Shunlin Ren - Richmond VA, US
William M. Pandak - Richmond VA, US
International Classification:
A61K 31/575, C07J 9/00, A61P 3/06, A61P 9/10, A61P 1/16, A61P 7/00, A61P 29/00, C12N 5/00
Abstract:
The sulfated oxysterol 5-cholesten-3β, 25-diol 3-sulphate, a nuclear cholesterol metabolite that decreases lipid biosynthesis and increases cholesterol secretion and degradation, is provided as an agent to lower intracellular and serum cholesterol and/or triglycerides, and to prevent or treat lipid accumulation-associated inflammation and conditions associated with such inflammation. Methods which involve the use of this sulfated oxysterol to treat conditions associated with high cholesterol and/or high triglycerides and/or inflammation (e.g. hypercholesterolemia, hypertriglyceridemia, non-alcoholic fatty liver diseases, atherosclerosis, etc.) are also provided.