DR. WILLIAM MATTHEW GREENBERG, PHARM.D.
Pharmacy at Arbor Dr, San Diego, CA
License number
California 31113
Category
Pharmacy
Type
Pharmacotherapy
Address
Address
2
200 W Arbor Dr, San Diego, CA 92103
13151 Ridgedale Dr, Poway, CA 92064
13151 Ridgedale Dr, Poway, CA 92064
Phone
(619) 543-5943
(619) 543-6784 (Fax)
(858) 679-7895
(619) 543-6784 (Fax)
(858) 679-7895
Personal information
See more information about WILLIAM MATTHEW GREENBERG at radaris.comName
Address
Phone
5638 W Avenue L1, Lancaster, CA 93536
3425 Highwood Ct APT 142, Simi Valley, CA 93063
7830 Lena Ave, West Hills, CA 91304
6449 Mclennan Ave, Van Nuys, CA 91406
3368 Edgeview St, San Marcos, CA 92078
Professional information
Pharm.d., Bcps
Position:
Pharmacist at Palomar Health
Location:
Greater San Diego Area
Industry:
Hospital & Health Care
Work:
Palomar Health
since Aug 2010
-
Pharmacist
UCSD Skaggs School of Pharmacy & Pharmaceutical Sciences
2001 - Dec 2012
-
Assistant Clinical Professor (adjunct)
UCSD Medical Center
Mar 2001 - Nov 2010
-
Staff Phamacist II
Education:
University of Southern California 1973 - 1977
Pharm.D.
Pharm.D.
Amidases, Nucleic Acids Encoding Them And Methods For Making And Using Them
US Patent:
2006025, Nov 16, 2006
Filed:
Jan 28, 2003
Appl. No.:
10/502832
Inventors:
Nelson Barton - SAN DIEGO CA, US
David Weiner - Del Mar CA, US
William Greenberg - San Diego CA, US
Samantha Luu - San Diego CA, US
Kristine Chang - San Diego CA, US
Elizabeth Waters - San Diego CA, US
David Weiner - Del Mar CA, US
William Greenberg - San Diego CA, US
Samantha Luu - San Diego CA, US
Kristine Chang - San Diego CA, US
Elizabeth Waters - San Diego CA, US
International Classification:
A01K 67/027, A01H 5/00, C12N 1/21, C12Q 1/68, C07H 21/04, C07D 501/00, C12N 9/80, C07D 501/14, C12N 15/74, C12N 15/82, C12P 35/02
US Classification:
800018000, 536023200, 435006000, 435228000, 435252300, 435471000, 800288000, 540222000, 435051000
Abstract:
This invention provides amidases, polynucleotides encoding the amidases, methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides enzymes having secondary amidase activity, e.g., having activity in the hydrolysis of amides, including enzymes having peptidase, protease and/or hydantoinase activity. In alternative aspects, the enzymes of the invention can be used to used to increase flavor in food (e.g., enzyme ripened cheese), promote bacterial and fungal killing, modify and de-protect fine chemical intermediates, synthesize peptide bonds, carry out chiral resolutions, hydrolyze Cephalosporin C. The enzymes of the invention can be used to generate 7-aminocephalosporanic acid (7-ACA) and semi-synthetic cephalosporin antibiotics, including caphalothin, cephaloridine and cefuroxime. The enzymes of the invention can be used as antimicrobial agents, e.g., as cell wall hydrolytic agents. The invention also provides a fluorescent amidase substrate comprising 7-(ε-D-2-aminoadipoyladipoylamido)-4-methylcoumarin.
Enzymes Having Secondary Amidases Activity And Methods Of Use Thereof
US Patent:
2004002, Feb 5, 2004
Filed:
Jan 28, 2003
Appl. No.:
10/354437
Inventors:
Nelson Barton - San Diego CA, US
David Weiner - Del Mar CA, US
William Greenberg - San Diego CA, US
Samantha Luu - San Diego CA, US
Kristine Chang - San Diego CA, US
Elizabeth Waters - San Diego CA, US
David Weiner - Del Mar CA, US
William Greenberg - San Diego CA, US
Samantha Luu - San Diego CA, US
Kristine Chang - San Diego CA, US
Elizabeth Waters - San Diego CA, US
Assignee:
Diversa Corporation - San Diego CA
International Classification:
C12Q001/68, G06F019/00, G01N033/48, G01N033/50, C07H021/04, C12N009/80
US Classification:
435/006000, 435/069100, 435/228000, 435/320100, 435/325000, 536/023200, 702/019000
Abstract:
This invention provides amidases, polynucleotides encoding the amidases, methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides enzymes having secondary amidase activity, e.g., having activity in the hydrolysis of amides, including enzymes having peptidase, protease and/or hydantoinase activity. In alternative aspects, the enzymes of the invention can be used to used to increase flavor in food (e.g., enzyme ripened cheese), promote bacterial and fungal killing, modify and de-protect fine chemical intermediates, synthesize peptide bonds, carry out chiral resolutions, hydrolyze Cephalosporin C. The enzymes of the invention can be used to generate 7-aminocephalosporanic acid (7-ACA) and semi-synthetic cephalosporin antibiotics, including caphalothin, cephaloridine and cefuroxime. The enzymes of the invention can be used as antimicrobial agents, e.g., as cell wall hydrolytic agents. The invention also provides a fluorescent amidase substrate comprising 7-( -D-2-aminoadipoylamido)-4-methylcoumarin.
Aldolases, Nucleic Acids Encoding Them And Methods For Making And Using Them
US Patent:
7414119, Aug 19, 2008
Filed:
Aug 19, 2003
Appl. No.:
10/472157
Inventors:
William Greenberg - San Diego CA, US
Mark J. Burk - San Diego CA, US
Alexander Varvak - San Diego CA, US
Kelvin Wong - San Diego CA, US
Mark J. Burk - San Diego CA, US
Alexander Varvak - San Diego CA, US
Kelvin Wong - San Diego CA, US
Assignee:
Verenium Corporation - San Diego CA
International Classification:
C12N 15/60, C12N 15/62, C12N 15/79, C12N 9/88, C12N 17/06
US Classification:
536 232, 435 53, 435 691, 435 697, 435232, 4352523, 4353201, 536 234
Abstract:
The invention provides novel aldolases, nucleic acids encoding them and methods for making and using them, including chemoenzymatic processes for making β,δ-dihydroxyheptanoic acid side chains and compositions comprising these side chains, e. g. , [R-(R*,R*)]-2-(4-fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-(phenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid (atorvastatin, LIPITOR™), rosuvastatin (CRESTOR™), fluvastatin (LESCOL™), related compounds and their intermediates.
Methods And Compositions For Preparation Of Selectively Protected Carbohydrates
US Patent:
2009012, May 14, 2009
Filed:
Jun 18, 2008
Appl. No.:
12/141348
Inventors:
Frances H. Arnold - La Canada CA, US
Yuuichi Mitsuda - Osaka, JP
Michael M. Chen - Pasadena CA, US
Clay Bennett - Medford MA, US
William Greenberg - San Diego CA, US
Jared Crawford Lewis - Pasadena CA, US
Sabine Bastian - Saarbruecken, DE
Yuuichi Mitsuda - Osaka, JP
Michael M. Chen - Pasadena CA, US
Clay Bennett - Medford MA, US
William Greenberg - San Diego CA, US
Jared Crawford Lewis - Pasadena CA, US
Sabine Bastian - Saarbruecken, DE
Assignee:
The California Institute of Technology - Pasadena CA
International Classification:
C40B 30/08, C12P 19/00, C12P 19/02, C12N 9/02, C12N 15/11, C12N 15/00, C12N 1/21, C12Q 1/26
US Classification:
506 11, 435 72, 435105, 435189, 536 232, 4353201, 43525233, 435 25
Abstract:
The disclosure relates to engineered P450 polypeptides and use of such polypeptides in chemoenzymatic methods to construct selectively protected carbohydrates, which are useful as building blocks for preparation of carbohydrate derivatives and oligosaccharides
Nucleoside Analog Libraries
US Patent:
2004000, Jan 8, 2004
Filed:
Nov 27, 2002
Appl. No.:
10/306253
Inventors:
Robert Epple - San Diego CA, US
William Greenberg - San Diego CA, US
Romas Kudirka - La Crescenta CA, US
William Greenberg - San Diego CA, US
Romas Kudirka - La Crescenta CA, US
Assignee:
IRM LLC, a Delaware Limited Liability Company - Hamilton
International Classification:
C07H019/067, C07H019/073, C08G063/48, C08G063/91
US Classification:
525/054200, 536/028500
Abstract:
The present invention provides combinatorial libraries of nucleoside analog compounds and methods of making the libraries. In addition, the present invention provides methods of assaying the libraries for agonists or antagonists of a broad array of targets of therapeutic importance.
Chemoenzymatic Methods For The Synthesis Of Statins And Statin Intermediates
US Patent:
8148324, Apr 3, 2012
Filed:
Feb 15, 2008
Appl. No.:
12/032337
Inventors:
William Greenberg - San Diego CA, US
Mark J. Burk - San Diego CA, US
Alexander Varvak - San Diego CA, US
Kelvin Wong - San Diego CA, US
Mark J. Burk - San Diego CA, US
Alexander Varvak - San Diego CA, US
Kelvin Wong - San Diego CA, US
Assignee:
Verenium Corporation - San Diego CA
International Classification:
C07K 14/00, C12P 21/00
US Classification:
514 2, 435 681
Abstract:
The invention provides aldolases, nucleic acids encoding them and methods for making and using them, including chemoenzymatic processes for making β,δ-dihydroxyheptanoic acid side chains and compositions comprising these side chains, e. g. , [R—(R*,R*)]-2-(4-fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-(phenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid (atorvastatin, LIPITOR™), rosuvastatin (CRESTOR™), fluvastatin (LESCOL™), related compounds and their intermediates.
Nucleoside Analog Libraries
US Patent:
7034147, Apr 25, 2006
Filed:
May 8, 2003
Appl. No.:
10/379607
Inventors:
Robert Epple - San Diego CA, US
William Greenberg - San Diego CA, US
Romas Kudirka - La Crescenta CA, US
William Greenberg - San Diego CA, US
Romas Kudirka - La Crescenta CA, US
Assignee:
IRM LLC - Hamilton
International Classification:
C07H 21/00
US Classification:
536 253, 435 6
Abstract:
The present invention provides combinatorial libraries of nucleoside analog compounds and methods of making the libraries. In addition, the present invention provides methods of assaying the libraries for agonists or antagonists of a broad array of targets of therapeutic importance.
Methods For Making Simvastatin And Intermediates
US Patent:
7700329, Apr 20, 2010
Filed:
Oct 20, 2004
Appl. No.:
10/576122
Inventors:
Brian Morgan - San Diego CA, US
Mark Burk - San Diego CA, US
Michael Levin - San Diego CA, US
Zuolin Zhu - San Diego CA, US
Jennifer Chaplin - San Diego CA, US
Karen Kustedjo - San Diego CA, US
Zilin Huang - Bellevue WA, US
William Greenberg - San Diego CA, US
Mark Burk - San Diego CA, US
Michael Levin - San Diego CA, US
Zuolin Zhu - San Diego CA, US
Jennifer Chaplin - San Diego CA, US
Karen Kustedjo - San Diego CA, US
Zilin Huang - Bellevue WA, US
William Greenberg - San Diego CA, US
International Classification:
C12P 17/06, C12P 17/12, C12P 17/18
US Classification:
435125, 435123, 435158
Abstract:
The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e. g. , esterases, are used in the methods of the invention.
Methods For Making Simvastatin And Intermediates
US Patent:
2011005, Mar 10, 2011
Filed:
Apr 19, 2010
Appl. No.:
12/763198
Inventors:
Brian Morgan - San Diego CA, US
Mark Burk - San Diego CA, US
Michael Levin - San Diego CA, US
Zuolin Zhu - Huaibie, CN
Jennifer Chaplin - San Diego CA, US
Karen Kustedjo - San Diego CA, US
Zilin Huang - San Leandro CA, US
William Greenberg - San Diego CA, US
Mark Burk - San Diego CA, US
Michael Levin - San Diego CA, US
Zuolin Zhu - Huaibie, CN
Jennifer Chaplin - San Diego CA, US
Karen Kustedjo - San Diego CA, US
Zilin Huang - San Leandro CA, US
William Greenberg - San Diego CA, US
International Classification:
C12P 17/06, C12N 9/14, C12P 7/42
US Classification:
435125, 435195, 435146
Abstract:
The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention.