Inventors:
John Hollingsworth - Durham NC, US
William Michael Foster - Durham NC, US
Erin Potts Kant - Chapel Hill NC, US
Zhuowei Li - Chapel Hill NC, US
International Classification:
A61K 31/352, A61P 11/00, C12Q 1/68, A61P 11/08, A61K 31/56, C12Q 1/32, A61K 31/343, A61P 11/06
US Classification:
514171, 514454, 514468, 435 26, 435 611
Abstract:
Methods of treating lung diseases comprising administering inducers of NAD(P)H:quinone oxidoreductase 1 (NQO1) are disclosed. Inducers of NQO1 include naphthoquinones such as β-lapachone. Methods of predicting whether a subject with a lung disease will respond to treatment with a naphthoquinone are also described herein.