WILLIAM LEE
Marriage and Family Therapists in Cambridge, MA

2003006, Apr 10, 2003

Apr 19, 2002

10/126297

William Lee - Cambridge MA, US
Kyoichi Saito - Tokyo, JP

C12Q001/68, G01N033/53, G01N033/542, A61K039/395, C12M001/34

424/140100, 435/006000, 435/007900, 435/287200

Compositions are provided herein comprising a base material having engrafted polymer brushes. The polymer brushes further comprise one or more functional groups immobilized along the surface of the brushes in a plurality of layers, which confer functional properties to the base material compositions. Methods of using these compositions include deoxygenation of a sample solution, hydrolysis of denaturing agents in a sample solution, resolution of racemic mixtures in a sample solution, and purification, and concentration of target compounds.

6861001, Mar 1, 2005

Dec 1, 2000

09/728882

William Lee - Cambridge MA, US
Jeffrey R. Morgan - Sharon MA, US
Martin L. Yarmush - Newton MA, US

The General Hospital Corporation - Boston MA

B01D061/00

210651, 210645, 210650, 210653, 21050036, 21050035

The invention is based on the discovery that certain membranes, which include side chains or molecular “brushes” having, for example, tertiary amino functional groups, can be used as highly effective filters to capture viruses/virus particles from liquids without removal of proteins. New methods based on this discovery include removing viruses from liquids such as blood or plasma, removing viruses from pharmaceuticals, concentrating and/or purifying viruses, e. g. , for use in gene therapy, and producing recombinant viruses in new bioreactors. The invention also includes new methods of therapy or adjunct therapy for viral infections, in which a patient's blood or plasma is filtered through the membranes to remove viruses to reduce the viral load. The invention also includes new bioreactors and viral filters containing the membranes.

2008007, Mar 20, 2008

Apr 20, 2007

11/738123

William Lee - Cambridge MA, US
Kyoichi Saito - Tokyo, JP

C12P 1/00, B01L 3/00, B05D 5/00, B32B 1/02, B32B 1/08, B32B 27/00, B32B 3/24, B32B 5/00, C12N 11/00

435041000, 422102000, 427256000, 428138000, 428195100, 428035700, 428036900, 435174000

Compositions are provided herein comprising a base material having engrafted polymer brushes. The polymer brushes further comprise one or more functional groups immobilized along the surface of the brushes in a plurality of layers, which confer functional properties to the base material compositions. Methods of using these compositions include deoxygenation of a sample solution, hydrolysis of denaturing agents in a sample solution, resolution of racemic mixtures in a sample solution, and purification, and concentration of target compounds.

7160464, Jan 9, 2007

Dec 21, 2004

11/018939

William Lee - Cambridge MA, US
Jeffrey R. Morgan - Sharon MA, US
Martin L. Yarmush - Newton MA, US

The General Hospital Corporation - Boston MA

B01D 61/00, B01D 63/00, B01D 15/04

210651, 210645, 210650, 210653, 21050035, 21050036, 2103218, 210175, 210184, 21050037, 435325

The invention is based on the discovery that certain membranes, which include side chains or molecular “brushes” having, for example, tertiary amino functional groups, can be used as highly effective filters to capture viruses/virus particles from liquids without removal of proteins. New methods based on this discovery include removing viruses from liquids such as blood or plasma, removing viruses from pharmaceuticals, concentrating and/or purifying viruses, e. g. , for use in gene therapy, and producing recombinant viruses in new bioreactors. The invention also includes new methods of therapy or adjunct therapy for viral infections, in which a patient's blood or plasma is filtered through the membranes to remove viruses to reduce the viral load. The invention also includes new bioreactors and viral filters containing the membranes.

2005011, May 26, 2005

Jun 9, 2004

10/864705

William Lee - Cambridge MA, US
Kyoichi Saito - Tokyo, JP

B05D003/00, C12Q001/68, G01N033/53, C12M001/34

435006000, 435007100, 435287200, 436518000, 427002110

Compositions are provided herein comprising a material having engrafted polymer brushes. The polymer brushes further comprise one or more functional groups immobilized along the surface of the brushes in a plurality of layers, which confer functional properties to the material compositions. These materials are useful in material libraries for high throughput separation studies, and for the isolation or transfection of microorganisms and cells.

2006004, Feb 23, 2006

Mar 15, 2005

11/085023

William Lee - Cambridge MA, US
Saito Kyoichi - Tokyo, JP

C12Q 1/68, C12M 1/34

435006000, 435287200

Compositions are provided herein comprising a base material having engrafted polymer brushes. The polymer brushers further comprise one or more functional groups immobilized along the surface of the brushes in a plurality of layers, which confer functional properties to the base material compositions. Methods of using these compositions include deoxygenation of a sample solution, hydrolysis of denaturing agents in a sample solution, resolution of racemic mixtures in a sample solution, and purification, and concentration of target compounds.