Inventors:
Wenbin Lin - Chapel Hill NC, US
William J. Rieter - Charleston SC, US
International Classification:
A61K 9/14, C08F 26/10, B32B 5/00, A61K 31/79, A61K 51/00, A61K 49/00, A61B 5/055, A61K 9/127, C12N 5/00, A61P 35/00, B82Y 5/00
US Classification:
424 165, 525370, 428402, 424 7824, 424 91, 424 93, 424490, 424497, 424450, 435375, 977773, 977906, 977915
Abstract:
The presently disclosed subject matter provides nanoscale coordination polymers for use as anticancer agents and as dual anticancer/imaging agents. The nanoscale coordination polymers can comprise a plurality of platinum metal complexes; nonplatinum anticancer drug bridging ligands complexed to multiple metal centers; or combinations thereof. The nanoscale coordination polymers can be targeted for delivery to cancer cells. They can also comprise stabilizing agents to allow for controlled and/or sustained release of anticancer agents in vivo.