Inventors:
William J. Polvino - Tinton Falls NJ, US
Richard Nelson - Morristown NJ, US
William R. Mann - Sparta NJ, US
Assignee:
HELSINN THERAPEUTICS (U.S.), INC. - Bridgewater NJ
International Classification:
A61K 38/08, A61P 1/02
Abstract:
The present invention provides a method of stimulating the motility of the gastrointestinal system in a subject in need thereof, wherein the subject suffers from maladies (i.e., disorders, diseases, conditions, or drug- or surgery-induced dysfunction) of the gastrointestinal system, by administering to the subject a ghrelin mimetic, or pharmaceutically acceptable salt thereof. The invention also provides a method of treating a gastrointestinal malady by co-administering a ghrelin mimetic with a laxative, a Hreceptor antagonist, a serotonin receptor agonist, pure or mixed, an antacid, an opioid antagonist, a proton pump inhibitor, a motilin receptor agonist, dopamine antagonist, a cholinergic agonist, a cholinesterase inhibitor, somatostatin, octreotide, or any combination thereof.