WILLIAM J CHIN
Broker in Wellesley, MA
License number
Massachusetts 137456
Issued Date
May 9, 1990
Expiration Date
Dec 21, 2006
Type
Broker
Address
Address
Wellesley, MA 02481
Professional information
Dna Encoding A Pituitary-Specific Thyroid Hormone Receptor
US Patent:
5284999, Feb 8, 1994
Filed:
May 13, 1993
Appl. No.:
8/069643
Inventors:
William W. Chin - Wellesley MA
Richard A. Hodin - Brookline MA
Mitchell A. Lazar - Havertown PA
Richard A. Hodin - Brookline MA
Mitchell A. Lazar - Havertown PA
Assignee:
Brigham and Women's Hospital - Boston MA
International Classification:
C12N 1512
US Classification:
4352523
Abstract:
The invention relates to the purification and cloning of a receptor for thyroid hormone. The receptor is designated PSTHR and is related to hormone receptors encoded by the genes erbA. alpha. -1, erbaA. alpha. -2 and erbA. beta. -1. The gene encoding PSTHR, erbA. beta. -2, is partially homologous to the erbA. beta. -1. However, PSTHR differs from the product of erbA. beta. -1 in that its expression is limited to the anterior pituitary gland. The invention additionally concerns the uses for PSTHR in the diagnosis and therapy of human conditions.