WILLIAM J. ALBRECHT JR.
Plumbers at Commerce Blvd, Cincinnati, OH

4146624, Mar 27, 1979

Sep 14, 1970

5/072171

William L. Albrecht - Cincinnati OH
Robert W. Fleming - Cincinnati OH

Richardson-Merrell Inc. - Wilton CT

A61K 31335, A61K 31395, A61K 31445, A61K 31535

42424857

Antiviral compositions and methods of inhibiting or inactivating viruses by administering to hosts an effective quantity of an active ingredient are disclosed herein. The active ingredients are those compounds having the formula ##STR1## wherein A is a straight or branched alkylene chain of from 1 to 6 carbon atoms and each Y is the group (A) ##STR2## wherein R. sup. 1 and R. sup. 2 are each individually selected from hydrogen, lower alkyl of from 1 to 4 carbon atoms, cycloalkyl of from 3 to 6 carbon atoms, alkenyl of from 3 to 6 carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group; or (B) ##STR3## wherein n is a whole integer of 4, 5 or 6 and R. sup. 3 is hydrogen, lower alkyl of from 1 to 4 carbon atoms, phenyl or benzyl and can be attached to any one of the carbon atoms of the heterocyclic group; or (C) ##STR4## wherein X is oxygen or N--R. sup. 4 and R. sup. 4 is hydrogen or lower alkyl of from 1 to 4 carbon atoms, Or pharmaceutically acceptable acid addition salts of said compounds.

4064347, Dec 20, 1977

Feb 2, 1973

5/328912

Robert W. Fleming - Wyoming OH
Arthur D. Sill - Greenhills OH
William L. Albrecht - Cincinnati OH
Stephen W. Horgan - Cincinnati OH

Richardson-Merrell Inc. - Wilton CT

C07D29510

544 79

The novel bis-basic ketones of fluorene and fluorenone of the present invention have antiviral activity when administered orally and parenterally. These compounds are represented by the following formula: ##STR1## wherein Z is oxygen or H. sub. 2 ; each A is a straight or branched alkylene chain having from 1 to about 6 carbon atoms; and each Y is A. the group ##STR2## wherein R. sup. 1 and R. sup. 2 are individually hydrogen, (lower)alkyl having from 1 to about 6 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms, alkenyl of from 3 to 6 carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group; or B. the group ##STR3## WHEREIN N IS A WHOLE INTEGER FROM 4 TO 6, AND R. sup. 3 is hydrogen, (lower)alkyl of 1 to about 4 carbon atoms, phenyl, or benzyl and can be linked to any one of the carbon atoms of the heterocyclic group; or C. the group ##STR4## wherein X is oxygen or NR. sup. 4, and R. sup.

4230715, Oct 28, 1980

Sep 4, 1979

6/071814

William L. Albrecht - Cincinnati OH
Winton D. Jones - Cincinnati OH

Richardson-Merrell Inc. - Wilton CT

A61K 3141, A61K 3162, C07D24912

424269

Compounds of the formula ##STR1## wherein R. sub. 1 is H or NH. sub. 2 ; R. sub. 2 is C. sub. 1-6 straight or branched chain alkyl; --CH. sub. 2 OH; --(CH. sub. 2). sub. n --O--(CH. sub. 2). sub. m --CH. sub. 3 ; phenyl; or --(CH. sub. 2). sub. p NH. sub. 2 ; n is 1-3; m is 0-3; and p is 1-5; and the pharmaceutically acceptable acid addition salts of those compounds of basic character, have antisecretory activity.

3932424, Jan 13, 1976

Jul 31, 1974

5/493271

William L. Albrecht - Cincinnati OH
Robert W. Fleming - Cincinnati OH

Richardson-Merrell Inc. - Wilton CT

C07D20988

26029361

The novel bis-basic ethers of carbazole of the present invention have useful antiviral properties. These new compounds are represented by the formula ##SPC1## Wherein Z is hydrogen or lower alkyl having from 1 to 4 carbon atoms; and each X is ##EQU1## A. the group -A-N wherein each A is a straight or branched alkylene chain having from 2 to 6 carbon atoms; R and R. sup. 1 are individually hydrogen or lower alkyl having from 1 to 6 carbon atoms; or each set of R and R. sup. 1 taken together with the nitrogen atom to which they are attached is a saturated monocyclic heterocyclic group such as pyrrolidino or piperidino; or B. the group ##SPC2## Wherein n is a whole integer from 0 to 2, m is 1 or 2, and R. sup. 2 is hydrogen or lower alkyl having from 1 to 4 carbon atoms. This invention also includes pharmaceutically acceptable acid addition salts of the bases represented by Formula I.

3946021, Mar 23, 1976

Jun 28, 1973

5/374350

William L. Albrecht - Cincinnati OH
Robert W. Fleming - Cincinnati OH

Richardson-Merrell Inc. - Wilton CT

C07D29512

26029361

The novel bis-basic ketones of carbazole of the present invention have antiviral activity when administered orally and parenterally. These compounds are represented by the following formula: ##SPC1## Wherein Z is hydrogen or lower alkyl having from 1 to 4 carbon atoms; A is a straight or branched alkylene chain having from 1 to about 6 carbon atoms; and each Y is A. the group ##EQU1## wherein R. sup. 1 and R. sup. 2 are individually hydrogen or lower alkyl having from 1 to about 4 carbon atoms; or B. the group ##SPC2## Wherein n is a whole integer of 4 or 5, and R. sup. 3 is hydrogen or lower alkyl having from 1 to about 4 carbon atoms and can be linked to any one of the carbon atoms of the heterocyclic group; or C. the group ##SPC3## Wherein X is oxygen or NR. sup. 4, and R. sup. 4 is hydrogen or lower alkyl of from 1 to about 4 carbon atoms; Or a pharmaceutically acceptable acid addition salt of said base.

3952014, Apr 20, 1976

Aug 18, 1969

4/851098

William L. Albrecht - Cincinnati OH
Robert W. Fleming - Cincinnati OH

Richardson-Merrell Inc. - Wilton CT

C07D33376

2603293

Novel bis-basic esters and amides of dibenzothiophene of the formula ##SPC1## Wherein: A. each of R. sup. 1 and R. sup. 2 is hydrogen, (lower)alkyl, cycloalkyl of 3 to 6 ring carbon atoms, alkenyl of 3 to 6 carbon atoms having the vinyl unsaturation in other than the 1-position of the alkenyl group, or each set of R. sup. 1 and R. sup. 2 taken together with the nitrogen atom to which they are attached is pyrrolidino, piperidino, N-(lower)alkylpiperazino, or morpholino; B. each A is alkylene of 2 to about 8 carbon atoms and separates its adjacent Y and amino nitrogen by an alkylene chain of at least 2 carbon atoms; C. each Y is oxygen, or N--R wherein R is hydrogen or (lower)alkyl of 1 to 4 carbon atoms; or a pharmaceutically acceptable acid addition salt thereof. These compounds can be used as pharmaceuticals for preventing or inhibiting a viral infection.

3954983, May 4, 1976

Apr 28, 1975

5/571941

William L. Albrecht - Cincinnati OH
Francis W. Sweet - Cincinnati OH

Richardson-Merrell Inc. - Wilton CT

C07D28520

424246

Novel triazolobenzocycloalkylthiadiazines, their preparation, and use as central nervous system antidepressants.

3962451, Jun 8, 1976

Jun 4, 1974

5/476331

William L. Albrecht - Cincinnati OH
Robert W. Fleming - Ann Arbor MI

Richardson-Merrell Inc. - Wilton CT

A61K 31445

424267

Novel 3,6-bis-basic alkanes of carbazole, their preparation and use for the prevention and inhibition of viral infections are disclosed.

3954981, May 4, 1976

Apr 28, 1975

5/571940

William L. Albrecht - Cincinnati OH
Winton D. Jones - Cincinnati OH

Richardson-Merrell Inc. - Wilton CT

C07D28520, C07D28522

424246

Novel triazolocycloalkylhydrothiadiazines and their preparation, which are useful as antisecretory agents, central nervous system stimulants, and central nervous system depressants, are disclosed.

3983124, Sep 28, 1976

Dec 21, 1972

5/317238

William L. Albrecht - Cincinnati OH
Stephen W. Horgan - Cincinnati OH
Arthur D. Sill - Cincinnati OH
Robert W. Fleming - Ann Arbor MI

Richardson-Merrell Inc. - Wilton CT

C07D29512

26029362

Novel 2,7-bis-basic derivatives of fluorene, 9-fluorenol and 9-fluorenone, their preparation and use for the prevention and inhibition of virus infections are disclosed.