Inventors:
Tomas de Paulis - Hermitage TN
Dennis E. Schmidt - Nashville TN
William Hewlett - Nashville TN
Michael H. Ebert - Nashville TN
Assignee:
Vanderbilt University - Nashville TN
International Classification:
A61K 5100, A61M 3614
Abstract:
This invention provides compounds of the formula I ##STR1## wherein, R. sup. 1, R. sup. 2, and R. sup. 3 are independently �a first halogen atom,! fluorine, chlorine, bromine, iodine, alkyl, alkenyl, alkynyl, alkoxy, alkenoxy, or alkynoxy, wherein R. sup. 2 and R. sup. 3 can also independently be H, wherein at least one of R. sup. 1, R. sup. 2, and R. sup. 3 is �a second halogen atom! fluorine, bromine, iodine or is substituted with �a second halogen atom,! fluorine, bromine or iodine and R. sup. 4 is H or lower alkyl. The invention also provides precursors of formula I, radioactive analogs of formula I, and methods of using the compounds for the identification of 5-HT-3 receptors and the detection and treatment of abnormal conditions associated therewith.