WILLIAM G GAVIN
Veterinary in Dudley, MA
License number
Massachusetts 4224
Issued Date
May 25, 1994
Expiration Date
Feb 28, 2017
Type
Veterinarian
Address
Address
Dudley, MA 01571
Professional information
Methods Of Reconstructed Goat Embryo Transfer
US Patent:
6580017, Jun 17, 2003
Filed:
Apr 23, 1999
Appl. No.:
09/298971
Inventors:
Yann Echelard - Jamaica Plains MA
Esmail Behbodi - Shrewsbury MA
William Gavin - Dudley MA
David Melican - Fiskdale MA
Esmail Behbodi - Shrewsbury MA
William Gavin - Dudley MA
David Melican - Fiskdale MA
Assignee:
Genzyme Transgenics Corporation - Framingham MA
International Classification:
C12N 1500
US Classification:
800 24, 800 8, 800 14
Abstract:
The invention features methods of producing a mammal, e. g. , a cloned or transgenic mammal. The method includes maintaining a reconstructed embryo in culture until the embryo is in the 2 to 8 cell stage of embryogenesis, transferring the embryo at the 2 to 8 cell stage into a recipient mammal, and allowing the embryo to develop into a mammal.
Method And System For Fusion And Activation Following Nuclear Transfer In Reconstructed Embryos
US Patent:
2005017, Aug 11, 2005
Filed:
Jan 8, 2003
Appl. No.:
10/501305
Inventors:
William Gavin - Dudley MA, US
David Melican - Fiskdale MA, US
Robin Butler - Spencer MA, US
David Melican - Fiskdale MA, US
Robin Butler - Spencer MA, US
International Classification:
A01K067/027
US Classification:
800014000, 800015000, 800016000, 800017000
Abstract:
The present invention provides data to demonstrate that the re-fusion, of a mammalian karyoplast to an enucleated in vivo ovulated cocyte, following an unsuccessful initial simultaneous electrical fusion and activation event offers an additional alternative and improvement in the creation of activated and fused nuclear transfer-capable embryos for the production of live off-spring in various mammalian non-human species including goats, pigs, rodents, primates, rabbits and cattle. Additionally, multiple electrical pulses offers an alternative and more efficient activation method in a simultaneous fusion and activation methodology for viable offspring production in a animal nuclear transfer program.
Method And System For Fusion And Activation Following Nuclear Transfer In Reconstructed Embryos
US Patent:
2004013, Jul 8, 2004
Filed:
Jan 8, 2003
Appl. No.:
10/338546
Inventors:
William Gavin - Dudley MA, US
David Melican - Fiskdale MA, US
Robin Butler - Spencer MA, US
David Melican - Fiskdale MA, US
Robin Butler - Spencer MA, US
International Classification:
A01K067/00
US Classification:
800/008000
Abstract:
The present invention provides data to demonstrate that the re-fusion, of a mammalian karyoplast to an enucleated in vivo ovulated oocyte, following an unsuccessful initial simultaneous electrical fusion and activation event offers an additional alternative and improvement in the creation of activated and fused nuclear transfer-capable embryos for the production of live offspring in various mammalian non-human species including goats, pigs, rodents, primates, rabbits and cattle. Additionally, multiple electrical pulses offers an alternative and more efficient activation method in a simultaneous fusion and activation methodology for viable offspring production in a animal nuclear transfer program.
Method And System For Fusion And Activation Following Nuclear Transfer In Reconstructed Embryos
US Patent:
2006019, Aug 24, 2006
Filed:
Apr 20, 2006
Appl. No.:
11/408116
Inventors:
William Gavin - Dudley MA, US
David Melican - Fiskdale MA, US
Robin Butler - Spencer MA, US
David Melican - Fiskdale MA, US
Robin Butler - Spencer MA, US
International Classification:
A01K 67/027
US Classification:
800014000, 800015000, 800016000, 800017000, 800021000
Abstract:
The present invention provides data to demonstrate that the re-fusion, of a mammalian karyoplast to an enucleated in vivo ovulated oocyte, following an unsuccessful initial simultaneous electrical fusion and activation event offers an additional alternative and improvement in the creation of activated and fused nuclear transfer-capable embryos for the production of live offspring in various mammalian non-human species including goats, pigs, rodents, primates, rabbits and cattle. Additionally, multiple electrical pulses offers an alternative and more efficient activation method in a simultaneous fusion and activation methodology for viable offspring production in a animal nuclear transfer program.
Method For Selecting Cell Lines To Be Used For Nuclear Transfer In Mammalian Species
US Patent:
2003020, Oct 30, 2003
Filed:
Mar 25, 2003
Appl. No.:
10/396890
Inventors:
David Melican - Fiskdale MA, US
Robin Butler - Spencer MA, US
William Gavin - Dudley MA, US
Robin Butler - Spencer MA, US
William Gavin - Dudley MA, US
International Classification:
A01K067/027
US Classification:
800/014000, 800/015000, 800/016000, 800/017000
Abstract:
The present invention provides data to demonstrate that the fusion performance of a cell-line in procedures involving fusion and cleavage indices either alone or in combination are a means for selecting a cell lines that will be successful in a nuclear transfer or microinjection program. This technique and method of selecting a cell line offers an additional alternative and improvement in the creation of activated and fused nuclear transfer-capable embryos for the production of live offspring in various mammalian non-human species including goats, pigs, rodents, primates, rabbits and cattle.
Method For Selecting Cell Lines To Be Used For Nuclear Transfer In Mammalian Species
US Patent:
2006017, Aug 3, 2006
Filed:
Mar 28, 2006
Appl. No.:
11/391148
Inventors:
David Melican - Fiskdale MA, US
Robin Butler - Spencer MA, US
William Gavin - Dudley MA, US
Robin Butler - Spencer MA, US
William Gavin - Dudley MA, US
International Classification:
A01K 67/027
US Classification:
800014000, 800021000
Abstract:
The present invention provides data to demonstrate that the fusion performance of a cell-line in procedures involving fusion and cleavage indices either alone or in combination are a means for selecting a cell lines that will be successful in a nuclear transfer or microinjection program. This technique and method of selecting a cell line offers an additional alternative and improvement in the creation of activated and fused nuclear transfer-capable embryos for the production of live offspring in various mammalian non-human species including goats, pigs, rodents, primates, rabbits and cattle.
Transgenic And Cloned Mammals
US Patent:
2003017, Sep 18, 2003
Filed:
Apr 25, 2003
Appl. No.:
10/423792
Inventors:
Yann Echelard - Jamaica Plain MA, US
Esmail Behbodi - Shrewsbury MA, US
Carol Ziomek - Milford MA, US
William Gavin - Dudley MA, US
David Melican - Fiskdale MA, US
Esmail Behbodi - Shrewsbury MA, US
Carol Ziomek - Milford MA, US
William Gavin - Dudley MA, US
David Melican - Fiskdale MA, US
International Classification:
A01K067/027
US Classification:
800/014000, 800/021000
Abstract:
The invention features cloned and transgenic mammals, e.g., goats, which are made by introducing the genome of a somatic cell into an enucleated oocyte, preferably a naturally matured oocyte which in telophase, to form a reconstructed embryo.
Somatic Cell Line
US Patent:
2005019, Sep 1, 2005
Filed:
Sep 11, 2003
Appl. No.:
10/660384
Inventors:
Yann Echelard - Jamaica Plains MA, US
Esmail Behboodi - Shrewsbury MA, US
David Melican - Fiskdale MA, US
Carol Ziomek - Milford MA, US
William Gavin - Dudley MA, US
Esmail Behboodi - Shrewsbury MA, US
David Melican - Fiskdale MA, US
Carol Ziomek - Milford MA, US
William Gavin - Dudley MA, US
International Classification:
A01K067/027, C12N005/06
US Classification:
800014000, 800007000, 435325000
Abstract:
The invention features a purified embryonic or fetal caprine somatic cell. The somatic cell can be in a preparation of embryonic or fetal caprine somatic cells. In addition, the cell can be used to derive an embryonic or fetal caprine somatic cell line. The somatic cell can be a genetically engineered caprine somatic cell, e.g., a somatic cell which includes a transgenic sequence, or which a nucleic acid has been introduced.