William Frank Cole
Physician at Southwest, Houston, TX
License number
Colorado 21680
Issued Date
Jul 11, 1978
Renew Date
May 31, 1991
Expiration Date
May 31, 1991
Type
Physician
Address
Address
7777 Southwest Fwy SOUTHWEST, Houston, TX 77074
Professional information
Macrocyclic Bifunctional Chelating Agents
US Patent:
4678667, Jul 7, 1987
Filed:
Jul 2, 1985
Appl. No.:
6/751769
Inventors:
Claude F. Meares - Davis CA
Sally J. DeNardo - El Macero CA
William C. Cole - Houston TX
Min K. Mol - Davis CA
Sally J. DeNardo - El Macero CA
William C. Cole - Houston TX
Min K. Mol - Davis CA
Assignee:
501 Regents of the University of California - Berkeley CA
International Classification:
A61K 3900, A61K 3942, A61K 4300, A61K 4900
US Classification:
424 85
Abstract:
A copper chelate conjugate which is stable in human serum. The conjugate includes the copper chelate of a cyclic tetraaza di-, tri-, or tetra-acetic acid, a linker attached at one linker end to a ring carbon of the chelate, and a biomolecule joined at the other end of the linker. The conjugate, or the linker-copper chelate compound used in forming the conjugate, are designed for use in diagnostic and therapeutic applications which involve Cu(II) localization via the systemic route.