WILLIAM F DAVIS, MD
Osteopathic Medicine at Towne Blvd, Madison, WI

2009019, Aug 6, 2009

Jan 22, 2009

12/321655

William Davis - Madison WI, US
Mark A. Nottoli - Lake Bluff IL, US

A61K 31/593, A61K 31/122, A61P 35/00, A61P 9/12, A61P 25/24

424 941, 514167, 514168

A preparation containing vitamin D(cholecalciferol), preferably an edible oil, in an amount of 200 IU to 20,000 IU, preferably 1000 IU to 5000 IU, and most preferably about 1500 IU to 3500 IU, with about 2000 IU particularly preferred. Such a preparation is useful in providing adequate nutrition, in the prevention and/or treatment of Seasonal Affective Disorder (SAD), fall prevention, multiple sclerosis, chemoprevention of cancer, accelerated fracture healing, and metabolic syndrome. It acts as an anti-depressant, an anti-hypertensive for renovascular hypertension and high-renin hypertension; and is useful in hyperlipidemia treatment, as well as in the treatment of hypovitaminosis D in the renal failure population. The most important application to the present inventors is in treatment, prevention and also reversal of hypertension in renovascular and high-renin hypertension. The effective amount of vitamin D, based on blood serum content, is equal to or greater than 20 ng/mL, preferably equal to or greater than 40 ng/mL, and most preferably equal to or greater than 50 ng/mL, with no specific upper range, but preferably equal to or less than 200 ng/mL, and more preferably equal to or less than 100 ng/mL.