Inventors:
Mindy Grunzke - Denver CO, US
Neil Goldenberg - Aurora CO, US
Marilyn J. Manco-Johnson - Greenwood Village CO, US
Linda Jacobson - Denver CO, US
William E. Hathaway - Denver CO, US
Assignee:
The Regents of the University of Colorado, a body corporate - Denver CO
International Classification:
C12Q 1/56, C12M 1/34, G01N 21/64
Abstract:
Embodiments of the present invention report compositions and methods of analyzing thrombin and plasmin generation in a sample from a subject. In certain embodiments, the methods may comprise introducing at least one activator of coagulation and at least one activator of fibrinolysis to a sample and analyzing the sample for kinetic parameters related to thrombin and plasmin generation. In other embodiments, assays disclosed herein concern assessing net hemostatic balance of a subject for diagnostic and/or therapeutic applications.