WILLIAM EDWARD KLUNK
Medical Practice in Pittsburgh, PA
License number
Pennsylvania MD034216E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Pittsburgh, PA 15218
Personal information
See more information about WILLIAM EDWARD KLUNK at radaris.comName
Address
Phone
1098 Kohler Mill Rd, New Oxford, PA 17350
1108 Onondago St, Pittsburgh, PA 15218
2564 Municipal Rd, Dover, PA 17315
328 Highland Ave, Downingtown, PA 19335
400 Mckinley Ave, Hanover, PA 17331
Professional information
Amyloid Imaging As A Surrogate Marker For Efficacy Of Anti-Amyloid Therapies
US Patent:
8343457, Jan 1, 2013
Filed:
Mar 6, 2012
Appl. No.:
13/412823
Inventors:
William E. Klunk - Pittsburgh PA, US
Assignee:
University of Pittsburgh—of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
A61K 49/00, A61K 51/00
US Classification:
424 111, 424 165, 424 181, 424 189, 424 91, 424 98
Abstract:
The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to a patient in need thereof a compound of formula (I) or formula (II) or structures 1-45 and imaging the patient. After said imaging, at least one anti-amyloid agent is administered to said patient. Then, an effective amount of a compound of formula (I) or formula (II) or structures 1-45 is administered to the patient and the patient is imaged again. Finally, baseline levels of amyloid deposition in the patient before treatment with the anti-amyloid agent are compared with levels of amyloid deposition in the patient following treatment with the anti-amyloid agent.
Dr. William E Klunk, Pittsburgh PA - MD (Doctor of Medicine)
Specialties:
Geriatric Psychiatry
Address:
UPMC Western Psych Inst & Clin
3811 Ohara St, Pittsburgh 15213
(412) 624-2100 (Phone)
3811 Ohara St, Pittsburgh 15213
(412) 624-2100 (Phone)
Certifications:
Geriatric Psychiatry, 1991, Psychiatry, 1989
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
Washington Center / School of Medicine
Graduated: 1984
Washington Center / School of Medicine
Graduated: 1984
William Klunk, Pittsburgh PA
Work:
Western Psychiatric Institute & Clinic
3811 Ohara St, Pittsburgh, PA 15261 Univ. of Pittsburgh Physicians
130 Desoto St, Pittsburgh, PA 15213
3811 Ohara St, Pittsburgh, PA 15261 Univ. of Pittsburgh Physicians
130 Desoto St, Pittsburgh, PA 15213
Alkyl, Alkenyl And Alkynyl Chrysamine G Derivatives For Inhibition Of Cell Degeneration And Toxicity Associated With Amyloid Deposition
US Patent:
6133259, Oct 17, 2000
Filed:
Nov 9, 1998
Appl. No.:
9/188200
Inventors:
William E. Klunk - Pittsburgh PA
Jay W. Pettegrew - Pittsburgh PA
Chester A. Mathis - Pittsburgh PA
Jay W. Pettegrew - Pittsburgh PA
Chester A. Mathis - Pittsburgh PA
Assignee:
University of Pittsburgh - Pittsburgh PA
International Classification:
A61N 2528
US Classification:
5142305
Abstract:
Amyloid binding compounds which are non-azo derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloidosis, such as Down's Syndrome are described. Pharmaceutical compositions containing non-azo derivatives of Chrysamine G and methods using such compositions to prevent cell degeneration and amyloid-induced toxicity in amyloidosis associated conditions are also described. Methods using non-azo Chrysamine G derivatives to stain or detect amyloid deposits in biopsy or post-mortem tissue are also described. Methods using non-azo Chrysamine G derivatives to quantify amyloid deposits in homogenates of biopsy and post-mortem tissue are also described.
Thioflavin Derivates For Use In The Antemortem Diagnosis Of Alzheimer's Disease And In Vivo Imaging And Prevention Of Amyloid Deposition
US Patent:
2012009, Apr 19, 2012
Filed:
Dec 2, 2011
Appl. No.:
13/310243
Inventors:
William E. KLUNK - Pittsburgh PA, US
Yanming Wang - Imperial PA, US
Yanming Wang - Imperial PA, US
International Classification:
C07D 417/10, C07D 277/64
US Classification:
548156, 548152, 548178
Abstract:
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's Disease, familial Alzheimer's Disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.
Isotoypically-Labeled Benzothiazole Compounds As Imaging Agents For Amyloidogenic Proteins
US Patent:
2009014, Jun 4, 2009
Filed:
Nov 30, 2006
Appl. No.:
12/095760
Inventors:
William E. Klunk - Pittsburgh PA, US
Chester A. Mathis Jr. - Pittsburgh PA, US
Chester A. Mathis Jr. - Pittsburgh PA, US
International Classification:
A61K 49/00, C07D 277/66, G01N 33/53, A61K 31/428
US Classification:
424 91, 548152, 548178, 514367, 435 71
Abstract:
The present invention provides an isolated linezolid impurity, desfluoro linezolid, the preparation thereof and its use as a reference standard.
Heterocyclic Dye Compounds For In Vivo Imaging And Diagnosis Of Alzheimer's Disease
US Patent:
2009008, Apr 2, 2009
Filed:
Jul 15, 2005
Appl. No.:
11/632328
Inventors:
Brian Bacskai - Charlestown MA, US
Bradley T. Hyman - Swampscott MA, US
William E. Klunk - Pittsburgh PA, US
Chester A. Mathis - Pittsburgh PA, US
Timothy Swager - Newton MA, US
Evgueni Nesterov - Cambridge LA, US
Ivory Hills - Harleysville PA, US
Bradley T. Hyman - Swampscott MA, US
William E. Klunk - Pittsburgh PA, US
Chester A. Mathis - Pittsburgh PA, US
Timothy Swager - Newton MA, US
Evgueni Nesterov - Cambridge LA, US
Ivory Hills - Harleysville PA, US
Assignee:
The General Hospital Corporation - Boston MA
Massachusetts Institute of Technology - Cambridge MA
University of Pittsburg of the Commonwealth System of Higher Education - Pittsburg PA
Massachusetts Institute of Technology - Cambridge MA
University of Pittsburg of the Commonwealth System of Higher Education - Pittsburg PA
International Classification:
A61K 51/04, C07D 249/04, C07D 403/02, C07D 277/62, C07D 263/54, C07D 209/04, A61P 25/00, C07D 409/02, C07D 333/50, A61K 49/00, A61K 49/06
US Classification:
424 165, 548255, 544300, 548178, 548217, 548468, 549 59, 549 49, 424 91, 424 93
Abstract:
The present invention relates to the identification of compounds that are suitable for imaging amyloid deposits in living patients. The invention relates, in part, to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease. The present invention also relates to therapeutic uses for such compounds, as exemplified by compounds of the formula (1) in which Y is independently S, O, or N and m is 1, 2, or 3.
Benzothiazole Derivative Compounds, Compositions And Uses
US Patent:
8236282, Aug 7, 2012
Filed:
Sep 30, 2009
Appl. No.:
12/570379
Inventors:
William E. Klunk - Pittsburgh PA, US
Yanming Wang - Imperial PA, US
Yanming Wang - Imperial PA, US
Assignee:
University of Pittsburgh—of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
A61K 51/00, A61M 36/14
US Classification:
424 189, 424 111, 424 165, 424 181, 424 185
Abstract:
This invention provides benzothiazole derivative compounds, compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for detecting amyloid deposit(s) and for diagnosing a disease, disorder or condition characterized by amyloid deposit(s).
Isotopically-Labeled Benzofuran Compounds As Imaging Agents For Amyloidogenic Proteins
US Patent:
8138360, Mar 20, 2012
Filed:
Oct 10, 2006
Appl. No.:
12/064146
Inventors:
William E. Klunk - Pittsburgh PA, US
Assignee:
University of Pittsburgh—of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
C07D 307/79, A61K 31/343, G01N 33/53
US Classification:
549469, 514469, 436504
Abstract:
Benzofuran compounds which contain at least one detectable label selected from the group consisting of I, I, I, I, Br, Br, F, F, C, C, C and H are provided as amyloid imaging agents for detecting brain amyloid deposits as well as other amyloidogenic peptides associated with systemic or localized amyloidosis. Additionally, the compounds are useful for determining if patients, presenting with clinically confusing cases of dementia or presenting with mild cognitive impairment, have Alzheimer's disease. The compounds are additionally useful as surrogate markers for monitoring the efficacy of anti-amyloidosis therapies.
Isotopically-Labeled Benzofuran Compounds As Imaging Agents For Amyloidogenic Proteins
US Patent:
2012014, Jun 14, 2012
Filed:
Jan 26, 2012
Appl. No.:
13/359040
Inventors:
William E. KLUNK - Pittsburgh PA, US
International Classification:
A61K 49/00, G01N 33/53, C07D 307/78
US Classification:
424 91, 549469, 435 71
Abstract:
Benzofuran compounds which contain at least one detectable label selected from the group consisting of I, I, I, Br, Br, F, F, C, C, C and H are provided as amyloid imaging agents for detecting brain amyloid deposits as well as other amyloidogenic peptides associated with systemic or localized amyloidosis. Additionally, the compounds are useful for determining if patients, presenting with clinically confusing cases of dementia or presenting with mild cognitive impairment, have Alzheimer's disease. The compounds are additionally useful as surrogate markers for monitoring the efficacy of anti-amyloidosis therapies.