DR. WILLIAM DAVIS
Pharmacy in Tucson, AZ

4957941, Sep 18, 1990

Jan 9, 1990

7/463892

William M. Davis - Tucson AZ

United Pharmaceuticals, Inc. - Tucson AZ

A61K 31135, A61K 31395, A61K 3140, A61K 3141, A61K 31435, A61K 31495, A61K 31535, A61K 3154

514648

A new class of anti-spasmodic compounds having two branch chains is provided. The compounds have the general formula: ##STR1## where Y is H or OH; j is an integer from 0 to 4; k is an integer from 0 to 4, and wherein m is an integer from 1 to 4; n is an integer from 1 to 4; p is an integer from 1 to 4; and X may be nonexistent or may be O, S, NH or CH. sub. 2 or salts thereof, but when X is nonexistent the terminal group in which both the n-chain and the p-chain is a methyl group. ##STR2## The reaction was performed under reflux condensation. Following the reaction, which was usually complete within a few hours, the acid chlorides were vacuum distilled and reacted with a thiol compound as described above. The compounds of this invention are anti-muscarinic agents (cholinergic-muscarinic receptor antagonists) which inhibit the actions of acetylcholine on autonomic effectors innervated by postganglionic cholinergic nerves as well as on smooth muscle that lacks cholinergic innervation. Since a major component of parasympathetic control of smooth muscle occurs via muscarinic receptors, these compounds are effective as modifiers of smooth muscle activity.

4597857, Jul 1, 1986

Apr 8, 1985

6/721022

Daniel A. Norrgran - Tucson AZ
William B. Davis - Tucson AZ

Atlantic Richfield Company - Los Angeles CA

B03D 102

209166

A process for separating metal sulfide minerals from an ore containing metal sulfide minerals and silicate clays by subjecting the finely divided ore to anionic flotation using an anionic collector to produce a metal sulfide mineral concentrate containing silicate clay, separating the anionic collector from the concentrate and subjecting the concentrate to cationic flotation to selectively float silicate and produce as a residual product a metal sulfide mineral concentrate containing reduced amounts of silicate clay.

5120322, Jun 9, 1992

Jun 13, 1990

7/538025

William M. Davis - Tucson AZ
Milos Chvapil - Tucson AZ

Lathrotec, Inc. - Tucson AZ

A61M 532, A61M 2500

604265

A method of controlling scar formation in humans by applying a force to tissue in an amount to create a wound; applying a lathyrogenic agent to the wound; forming the wound into a predetermined stationary or moveable beneficial configuration; and maintaining the wound in the predetermined configuration and in contact with lathyrogenic agent during healing.

4707480, Nov 17, 1987

Oct 3, 1985

6/783311

William M. Davis - Tucson AZ

United Pharmaceuticals, Inc. - Tucson AZ

A61K 3121, A61K 31535, A61K 31445

514228

A method for inhibiting unplanned or premature detrusor muscle contractions while at the same time increasing the force of contraction of the detrusor muscle is provided. The method comprises administering to the patient a di-N-substituted aminoethyl ester of diphenylthioacetic acid having the formula: ##STR1## in which R represents a disubstituted amino radical of the group consisting of the diethylamino group, the morpholino group or the piperidino group.

4721722, Jan 26, 1988

Jul 12, 1985

6/754815

William M. Davis - Tucson AZ

United Pharmaceuticals, Inc. - Tucson AZ

A61K 31445, C07D40112

514317

A new class of anti-spasmodic compounds having two branch chains and containing quaternary nitrogen is provided. The compounds have the general formula: ##STR1## wherein R. sub. 1 and R. sub. 2 are defined hereinbelow and m is an integer from 0 to 3.

5130336, Jul 14, 1992

Nov 15, 1991

7/792799

William M. Davis - Tucson AZ

United Pharmaceuticals, Inc. - Tucson AZ

A61K 3121

514513

Treating a patient for neuro-muscular incontinence by administering a thiol-S-(2-diethyl-aminoethyl)-ester compound selected from the group consisting of trimethylacetyl-thio-S-(2-diethylaminoethyl)-ester, 1-cyclohexyl-1-phenylacetyl-thiol-S-(2-diethylaminoethyl)-ester, palmitoyl-thio-S-(2-diethylaminoethyl)-ester, 4-t-butyl-benzoyl-thiol-S-(2-diethylaminoethyl)-ester, phenylacetyl-thio-S-(2-diethylaminoethyl)-ester, 4-phenyl-butyryl-thio-S-(2-diethylaminoethyl)-ester, and 2-ethyl-butyryl-thio-S-(2-diethylaminoethyl)-ester.

5616119, Apr 1, 1997

Jun 2, 1995

8/458121

William M. Davis - Tucson AZ

Lathrotec, Inc. - Tucson AZ

A61N 130

604 19

Water-activated medicated apparatus including a base member at least partially formed from a water vapor permeable material and a water-activated or continuously released medicinal agent located within at least a portion of the base member, wherein the base member permits permeation of water vapor toward and into contact with the water-activated medicinal agent and diffusion of medicinal compound formed from the water-activated medicinal agent outwardly from said base member.

4647562, Mar 3, 1987

Feb 20, 1985

6/703263

William M. Davis - Tucson AZ

United Pharmaceuticals, Inc. - Tucson AZ

A61K 3154, A61K 31265, C07C153017, C07D27912

514222

A new class of anti-spasmodic compounds having three branch chains is provided. These compounds have the general formula: ##STR1## where R. sub. 1, R. sub. 2 and R. sub. 3 are saturated straight chain or branched alkyl groups contained from 1 to 8 carbon atoms, and are separated or linked to one another to form an aliphatic ring system. k is an integer from 0 to 5, and the total number of carbon atoms in R. sub. 1 plus R. sub. 2 plus R. sub. 3 plus k are equal to or less than 12. Furthermore, l is an integer from 1 to 3, m is an integer from 1 to 3, n is an integer from 1 to 3, and X may be nonexistent or may be O, S, NH or CH. sub. 2 or salts thereof. However, when X is nonexistent the terminal group in both the m chain and the n chain is a methyl group.

4678780, Jul 7, 1987

Oct 27, 1986

6/923623

William M. Davis - Tucson AZ

United Pharmaceuticals, Inc. - Tucson AZ

A61K 3155

514183

A new class of anti-spasmodic compounds having two branch chains is provided. The compounds have the general formula: ##STR1## where R, X, m, n and p are defined hereinbelow.

4652649, Mar 24, 1987

Feb 20, 1985

6/703264

William M. Davis - Tucson AZ

United Pharmaceuticals, Inc. - Tucson AZ

C07D40512

546196

A new class of anti-spasmodic compounds having two branch chains is provided. The compounds have the general formula: ##STR1## wherein the substituents are defined hereinbelow.