Inventors:
Philip A. Gale - Austin TX
Jonathan L. Sessler - Austin TX
John W. Genge - Austin TX
Vladimir A. Kral - Praha, CZ
Andrei Andrievsky - Rochester NY
Vincent Lynch - Austin TX
Petra I. Sansom - Edgewater NJ
William E. Allen - Austin TX
Christopher T. Brown - Austin TX
Andreas Gebauer - Austin TX
Assignee:
Board of Regents, University of Texas System - Austin TX
International Classification:
C07B 4700, C07D48722
Abstract:
The present invention provides calixpyrrole, calixpyridinopyrrole, and calixpyridine macrocycles, having 4, 5, 6, 7, or 8 heterocyclic rings, as well as syntheses, derivatives, conjugates, multimers, and solid supports thereof. Such macrocycles have proved to be effective and selective ion- and neutral molecule-binding agents forming supramolecular ensembles, and ion- and neutral molecule-separation agents. The macrocycles are fully meso-non-hydrogen-substituted porphyrinogens, a few molecules of which were previously known but not recognized as possessing anion- or molecule-binding properties. The binding mode is noncovalent, primarily that of hydrogen-bonding, thereby providing a new mode for liquid chromatography, that of Hydrogen Bonding Liquid Chromatography. Further useful applications of the macrocycles provided herein include environmental remediation by removal of undesired ions or neutral molecules, and removal of phosphate for kidney dialysis.