Inventors:
William R. HENDERSON - Seattle WA, US
Michael KAHN - Altadena CA, US
Assignee:
UNIVERSITY OF WASHINGTON - Seattle WA
INSTITUTE FOR CHEMICAL GENOMICS - Kirkland WA
International Classification:
A61K 31/4985, A61K 31/675, A61K 31/538, A61K 31/53
US Classification:
514 81, 514249, 5142305, 514243
Abstract:
The invention provides α-mimetic structure of formula (I), wherein A is —(C═O)—(CHR)— or —(C═O)—; B is —(NR)— or —(CHR)—; D is —(C═O)—(CHR)— or —(C═O)—; E is -(ZR)— or —(C═O)—, where Z is nitrogen or CH; —(XR)—, —(CHR)—(NR)—, —(C═O)—(XR)—, —(C═N—W—R)—, —(C═O)—, —(X—(C═O)—R)—, —(X—(C═O)—NRR)—, —(X—(SO)—R)—, or —(X—(C═O)—OR)—, where X is nitrogen or CH, and n=0 or 1; W is —Y(C═O)—, —(C═O)—(NH)—, —(SO)—, —(CHR)—, —(C═O)—(NR)—, substituted or unsubstituted oxadiazole, substituted or unsubstituted triazole, substituted or unsubstituted thiadiazole, substituted or unsubstituted 4,5-dihydrooxazole, substituted or unsubstituted 4,5-dihydrothiazole, substituted or unsubstituted 4,5-dihydroimidizole, or nothing, where Y is oxygen or sulfur; and R, R, R, R, R, R, R, R, RR, R, R, R, R, and Rare the same or different and independently selected from an amino acid side chain moiety or derivative thereof, the remainder of the molecule, a linker and a solid support, and stereoisomers, salts, and prodrugs thereof, provided that where B is —(CHR) and W is —Y(C═O)—, —(C═O)—(NH)—, —(SO)—, —(CHR)—, or —(C═O)—(N)—, G cannot be —(CHR)—, —(NR)—, —(C═O)—(CHR)—, —(C═O)—(NR)—, or no atom at all. Additionally, the invention provides methods wherein α-mimetic compounds are used to treat a disease or pathological condition.