WILLIAM A HUNKE
Pharmacy in Harleysville, PA

6486150, Nov 26, 2002

Apr 27, 2001

09/845453

William A. Hunke - Harleysville PA
Kathleen J. Illig - Phoenixville PA
Anand Kanike - Lansdale PA
Scott D. Reynolds - Perkiomenville PA
Stelios C. Tsinontides - Ambler PA
Anthony S. Al-Dehneh - Voorhees NJ
Hiren S. Patel - Parsippany NJ

Merck Co., Inc. - Rahway NJ

A61K 31407

51421013, 540350

The present invention involves a process for preparing a stable final formulation product of a compound of formula I, or its pharmaceutically acceptable salt, hydrate or solvate by incorporating a suitable carbon dioxide source to an unstable monosodium adduct of carbapenem antibiotic compound.

6548492, Apr 15, 2003

Oct 27, 2000

09/698808

Anthony Al-Dehneh - Elmwood Park NJ
William A. Hunke - Harleysville PA
Kathleen J. Illig - Phoenixville PA
Anand Kanike - Lansdale PA
Hiren Patel - Parsippany NJ
Scott D. Reynolds - Pekiomenville PA
Stelios C. Tsinontides - Ambler NJ

Merck Co., Inc. - Rahway NJ

C07D48704

51421013, 540350

A novel process for preparing a stabilized, lyophilized carbapenem, antibiotic formulation suitable for intravenous administration to patients in need thereof, wherein the active ingredient is of formula II: The process entails compounding a unstable, monosodium salt carbapenem with a sodium bicarbonate solution at a temperature range of from about 0° to about 5° C. while maintaining a pH between about 7. 0 and about 8. 0, filtering the resultant solution, bottling under sterile conditions, and lyophilizing to produce the formulation.

6136783, Oct 24, 2000

Jun 15, 1999

9/333245

Michael J. Kaufman - New Hope PA
William A. Hunke - Harleysville PA

Merck & Co., Inc. - Rahway NJ

A61K 3800

514 11

The invention is a pharmaceutical composition for intravenous administration to a patient comprising a) a pharmaceutically effective amount of a compound having the formula ##STR1## and the pharmaceutically acceptable salts thereof; b) a pharmaceutically acceptable amount of an excipient such as a bulking agent effective to form a lyophilized cake; and c) a pharmaceutically acceptable amount of acetate buffer effective to provide a pH of between about 4 and 7.

5952300, Sep 14, 1999

Mar 28, 1997

8/827510

Maneesh J. Nerurkar - Lansdale PA
William A. Hunke - Harleysville PA
Michael J. Kaufman - New Hope PA

Merck & Co., Inc. - Rahway NJ

A61K 3800, A61K 3812, A61K 950

514 11

The invention is a pharmaceutical composition for intravenous administration to a patient comprising a) a pharmaceutically effective amount of a compound having the formula ##STR1## and the pharmaceutically acceptable salts thereof; b) a pharmaceutically acceptable amount of an excipient such as a bulking agent effective to form a lyophilized cake; and c) a pharmaceutically acceptable amount of acetate buffer effective to provide a pH of between about 4 and 7.

5952323, Sep 14, 1999

Apr 22, 1998

9/064426

Jeffrey A. Zimmerman - Chalfont PA
John M. Williams - Belle Mead NJ
Paul A. Bergquist - Collegeville PA
Lisa M. DiMichele - Berkeley Heights NJ
David C. DuBost - Collegeville PA
Michael J. Kaufman - New Hope PA
Daniel R. Sidler - Whitehouse Station NJ
William A. Hunke - Harleysville PA

Merck & Co., Inc. - Rahway NJ

A61K 3140, C07D20716, C07D40312, C07D47720

514210

A pharmaceutical composition is disclosed which contains a compound of formula I: ##STR1## or a pharmaceutically acceptable salt, prodrug or hydrate thereof, in the stabilized form and/or in combination with a carbon dioxide source.