Inventors:
Wesley C. VAN VOORHIS - Seattle WA, US
Wilhelmus G.J. HOL - Kenmore WA, US
Eric T. LARSON - Bethel CT, US
Dustin James MALY - Seattle WA, US
Ethan MERRITT - Seattle WA, US
Kayode K. OJO - Federal Way WA, US
Assignee:
University of Washington through its Center for Commercialization - Seattle WA
International Classification:
A61K 31/519, A61K 31/4985, A61K 31/517, A61K 31/433, A61K 31/4045, A61K 31/404, A61K 31/52, A61K 31/44, A61K 31/553, A61K 31/5377, A61P 33/02, A61P 33/06, C07D 487/04, A61K 31/55
US Classification:
51421108, 544350, 514249, 544262, 5142621, 5142664, 514361, 514414, 51421207, 5142634, 514350, 5142345, 514418
Abstract:
Compositions and methods for the treatment of toxoplasmosis, caused by the infectious eukaryotic parasite () and for the treatment of cryptosporidiosis, caused by the infectious eukaryotic parasites () and () are described. In particular, the present disclosure is directed to compositions and methods for inhibiting either calcium dependent protein kinases (TgCDPKs) or and calcium dependent protein kinases (CpCDPKs) using pyrazolopyrimidine and/or imidazo[1,5-a]pyrazine inhibitors, of the formula,wherein the variables X, Y, Z, L, R, and Rare defined herein.