Inventors:
Robert L. Lawton - Gorham ME
Ashok P. Aiyappa - Scarborough ME
Wendy W. Liu - Shaker Heights OH
Brion Mermer - Cumberland ME
Hongliang Guo - Scarborough ME
Assignee:
Idexx Laboratories, Inc. - Westbrook ME
International Classification:
C12P 2108
Abstract:
The present invention provides methods and compositions for decreasing IgE levels in dogs. The methods and compositions are useful for treating allergic symptoms in dogs. The invention may comprise chimeric canine anti-IgE monoclonal antibody compositions and methods for using the compositions in the treatment of allergy. In preferred embodiments, the compositions of the present invention may act by binding soluble IgE in plasma, or by inhibiting IgE from binding to receptors on mast cells, B cells, and basophils.