Inventors:
Kenneth Eckels - Rockville MD, US
Joseph Putnak - Silver Spring MD, US
Doria Dubois - Wheaton MD, US
Bruce Innis - Haverford PA, US
Charles Hoke - Columbia MD, US
Wellington Sun - Rockville MD, US
Niranjan Kanesa-Thasan - Rockville MD, US
International Classification:
A61K 39/395, A61K 39/12
Abstract:
The present invention provides vaccine compositions of attenuated dengue virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides methods for stimulating the immune system of an individual to induce protection against all four dengue virus serotypes by administration of attenuated dengue-1, dengue-2, dengue-3, and dengue-4 virus.