WEIXIN LU, M.D.
Psychiatric at Loop, Houston, TX

6342216, Jan 29, 2002

Mar 17, 1999

09/271013

Isaiah J. Fidler - Houston TX
Zhongyun Dhong - Sugarland TX
Weixin Lu - Houston TX

The Board of Regents, The University of Texas System - Austin TX

A61K 4800

424 9321, 424 931, 424 932, 424 691, 424 695, 424 6951, 424 6952, 4353201, 435455, 435456, 435325, 435348, 536 231, 536 235, 536 2352

Provided are compositions and methods of use for insect cells comprising baculovirus encoding non-surface expressed proteins and peptides. The claimed invention particularly relates to compositions comprising insect cells containing baculovirus that express cytokines. Such compositions may be administered by, for example, direct intratumoral injection into tumors in mammals, resulting in tumor reduction or recission. Another aspect of the claimed invention concerns methods of promoting resistance to the reoccurence of tumors in mammals who have undergone such tumor recission. In a specific aspect of the claimed invention, the mammals are human subjects presenting with various forms of cancer.

2006022, Oct 12, 2006

Oct 21, 2003

10/532551

Isaiah Fidler - Houston TX, US
Zhongyun Dong - Sugar Land TX, US
Weixin Lu - Houston TX, US

A61K 38/21, A61K 38/20, A61K 38/19, C12P 21/02, C12N 5/06

424085100, 424085200, 424085500, 424085600, 424085700, 435069500, 435348000

The present invention provides for the treatment of a subject with occult brain metastasis. The treatment relies on administering to the subject a composition comprising an immunomodulatory polypeptide and a baculovirus-insect cell preparation. This composition has a unique ability to generate an anti-tumor immune response that is able to cross the blood-brain barrier.

6872385, Mar 29, 2005

May 31, 2001

09/872162

Isaiah J. Fidler - Houston TX, US
Zhongyun Dong - Sugar Land TX, US
Weixin Lu - Houston TX, US

Board of Regents, The University of Texas System - Austin TX

A61K038/21, A61K048/00, A61K045/00, A01N063/00, C12N015/63

424 856, 424 9321, 424 933, 4242781, 4353201, 435455

Disclosed are methods and compositions useful in the recruitment, activation and initiation of proliferation of immune cells. The instant invention relates to the discovery that specific insect cells and insect cell compositions exhibit adjuvant properties. The added benefit of this system is that the insect cells utilized may be transformed with an expression system and thus proteins may be introduced into the composition through direct protein expression by the cells. The claimed compositions and methods are particularly relevant in anti-tumor and cancer therapy. Of specific interest is the ability of the compositions of the invention to elicit a response that controls not only the primary tumor but also any metastatic cells or metastatic tumors which subsequently arise.

2005023, Oct 20, 2005

Mar 29, 2005

11/093269

Isaiah Fidler - Houston TX, US
Zhongyun Dong - Sugar Land TX, US
Weixin Lu - Houston TX, US

A61K048/00, A61K038/21, A61K038/20, C12N015/86, C12N005/08

424093210, 435366000, 435455000, 424085200, 424085700

Disclosed are methods and compositions useful in the recruitment, activation and initiation of proliferation of immune cells. The instant invention relates to the discovery that specific insect cells and insect cell compositions exhibit adjuvant properties. The added benefit of this system is that the insect cells utilized may be transformed with an expression system and thus proteins may be introduced into the composition through direct protein expression by the cells. The claimed compositions and methods are particularly relevant in anti-tumor and cancer therapy. Of specific interest is the ability of the compositions of the invention to elicit a response that controls not only the primary tumor but also any metastatic cells or metastatic tumors which subsequently arise.