DR. WEIWEN ZHENG, M.D.
Marriage and Family Therapists at Stockton St, San Francisco, CA
License number
California A92238
Category
Osteopathic Medicine
Type
Family Medicine
Address
Address
950 Stockton St SUITE 328, San Francisco, CA 94108
Phone
(415) 398-2698
(415) 398-2686 (Fax)
(415) 398-2686 (Fax)
Organization information
See more information about WEIWEN ZHENG at bizstanding.comWeiwen Zheng MD
950 Stockton St, San Francisco, CA 94108
Industry:
Family Doctor
Phone:
(415) 398-2698 (Phone)
Weiwen Zheng
Professional information
Dr. Weiwen Zheng - MD (Doctor of Medicine)
Hospitals:
Weiwen Zheng MD
950 Stockton St STE 328, San Francisco 94108
Saint Francis Memorial Hospital
900 Hyde St, San Francisco 94109
Weiwen Zheng MD
950 Stockton St STE 328, San Francisco 94108
Saint Francis Memorial Hospital
900 Hyde St, San Francisco 94109
950 Stockton St STE 328, San Francisco 94108
Saint Francis Memorial Hospital
900 Hyde St, San Francisco 94109
Weiwen Zheng MD
950 Stockton St STE 328, San Francisco 94108
Saint Francis Memorial Hospital
900 Hyde St, San Francisco 94109
Philosophy:
Caring, compassionate, and patient centered care.
Education:
Medical Schools
Sun Yat Sen University Med Science
Graduated: 1992
Sun Yat Sen University Med Science
Graduated: 1992
Methods Of Forming Targeted Liposomes Loaded With A Therapeutic Agent
US Patent:
2006014, Jul 6, 2006
Filed:
Feb 27, 2006
Appl. No.:
11/363986
Inventors:
Demetrios Papahadjopoulos - San Francisco CA, US
Keelung Hong - San Francisco CA, US
Weiwen Zheng - San Francisco CA, US
Dmitri Kirpotin - San Francisco CA, US
Keelung Hong - San Francisco CA, US
Weiwen Zheng - San Francisco CA, US
Dmitri Kirpotin - San Francisco CA, US
Assignee:
Regents of the University of California - Oakland CA
International Classification:
A61K 9/127, C12N 15/88
US Classification:
424450000, 435458000
Abstract:
The present invention provides for liposomes loaded with a therapeutic agent, which liposomes are targeted to a cell of interest by incubation with a targeting protein protein conjugated to a linker molecule comprising a hydrophobic domain, a hydrophilic polymer chain terminally attached to the hydrophobic domain, and a chemical group reactive to one or more functional groups on a protein molecule and attached to the hydrophilic polymer chain at a terminus contralateral to the hydrophobic domain, for a time sufficient to permit the hydrophobic domain to become stably associated with the liposome.
Kits For Forming Protein-Linked Lipidic Microparticles
US Patent:
6528087, Mar 4, 2003
Filed:
Jan 16, 2001
Appl. No.:
09/765107
Inventors:
Demetrios Papahadjopoulos - San Francisco CA
Keelung Hong - San Francisco CA
Weiwen Zheng - San Francisco CA
Dmitri B. Kirpotin - San Francisco CA
Keelung Hong - San Francisco CA
Weiwen Zheng - San Francisco CA
Dmitri B. Kirpotin - San Francisco CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 9127
US Classification:
424450
Abstract:
The present invention provides for lipid:nucleic acid complexes that have increased shelf life and high transfection activity in vivo following intravenous injection, and methods of preparing such complexes. The methods generally involve contacting a nucleic acid with an organic polycation to produce a condensed nucleic acid, and then combining the condensed nucleic acid with a lipid comprising an amphiphilic cationic lipid to produce the lipid:nucleic acid complex. This complex can be further stabilized by the addition of a hydrophilic polymer attached to hydrophobic side chains. The complex can also be made specific for specific cells, by incorporating a targeting moiety such as an Fabâ² fragment attached to a hydrophilic polymer. The present invention further relates to lipidic micro particles with attached proteins which have been first conjugated to linker molecules having a hydrophilic polymer domain and a hydrophobic domain capable of stable association with the microparticle, or proteins which have been engineered to contain a hydrophilic domain and a lipid moiety permitting stable association with the microparticle.
Preparation Of Stable Formulations Of Lipid-Nucleic Acid Complexes For Efficient In Vivo Delivery
US Patent:
6410049, Jun 25, 2002
Filed:
Oct 20, 1999
Appl. No.:
09/420908
Inventors:
Demetrios Papahadjopoulos - San Francisco CA
Keelung Hong - San Francisco CA
Weiwen Zheng - San Francisco CA
Keelung Hong - San Francisco CA
Weiwen Zheng - San Francisco CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 9127
US Classification:
424450, 536 231
Abstract:
The present invention provides for lipid:nucleic acid complexes that have increased shelf life and high transfection activity in vivo following intravenous injection, and methods of preparing such complexes. The methods generally involve contacting a nucleic acid with an organic polycation to produce a condensed nucleic acid, and then combining the condensed nucleic acid with a lipid comprising an amphiphilic cationic lipid to produce the lipid:nucleic acid complex. This complex can be further stabilized by the addition of a hydrophilic polymer attached to hydrophobic side chains. The complex can also be made specific for specific cells, by incorporating a targeting moiety such as an Fabâ² fragment attached to a hydrophilic polymer.
Lipidic Microparticles Linked To Multiple Proteins
US Patent:
6803053, Oct 12, 2004
Filed:
Jun 21, 2002
Appl. No.:
10/177939
Inventors:
Demetrios Papahadjopoulos - San Francisco CA
Keelung Hong - San Francisco CA
Weiwen Zheng - San Francisco CA
Dmitri B. Kirpotin - San Francisco CA
Keelung Hong - San Francisco CA
Weiwen Zheng - San Francisco CA
Dmitri B. Kirpotin - San Francisco CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 9127
US Classification:
424450, 530411, 530350
Abstract:
The invention provides lipidic microparticles stably associated with at least two different targeting moieties, which targeting moieties are attached to linker molecules comprising a hydrophilic domain and a hydrophobic domain. The targeting moieties can be antibodies, antibody fragments, hormones, growth factors, enzymes, or nucleic acid binding proteins, or other proteins. The targeting moieties can be chemically conjugated to the linker molecules, or they can be fused by recombinant techniques.
Preparation Of Stable Formulations Of Lipid-Nucleic Acid Complexes For Efficient In Vivo Delivery
US Patent:
2005017, Aug 4, 2005
Filed:
Apr 4, 2005
Appl. No.:
11/098888
Inventors:
Demetrios Papahadjopoulos - San Francisco CA, US
Keelung Hong - San Francisco CA, US
Weiwen Zheng - San Francisco CA, US
Keelung Hong - San Francisco CA, US
Weiwen Zheng - San Francisco CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K009/127, C12N015/88
US Classification:
435458000, 424450000
Abstract:
The present invention provides for lipid:nucleic acid complexes that have increased shelf life and high transfection activity in vivo following intravenous injection, and methods of preparing such complexes. The methods generally involve contacting a nucleic acid with an organic polycation to produce a condensed nucleic acid, and then combining the condensed nucleic acid with a lipid comprising an amphiphilic cationic lipid to produce the lipid:nucleic acid complex. This complex can be further stabilized by the addition of a hydrophilic polymer attached to hydrophobic side chains. The complex can also be made specific for specific cells, by incorporating a targeting moiety such as an Fab′ fragment attached to a hydrophilic polymer.
Methods Of Forming Protein-Linked Lipidic Microparticles, And Compositions Thereof
US Patent:
6210707, Apr 3, 2001
Filed:
May 12, 1998
Appl. No.:
9/076618
Inventors:
Demetrios Papahadjopoulos - San Francisco CA
Keelung Hong - San Francisco CA
Weiwen Zheng - San Francisco CA
Dmitri B. Kirpotin - San Francisco CA
Keelung Hong - San Francisco CA
Weiwen Zheng - San Francisco CA
Dmitri B. Kirpotin - San Francisco CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 9127
US Classification:
424450
Abstract:
The present invention provides for lipid:nucleic acid complexes that have increased shelf life and high transfection activity in vivo following intravenous injection, and methods of preparing such complexes. The methods generally involve contacting a nucleic acid with an organic polycation to produce a condensed nucleic acid, and then combining the condensed nucleic acid with a lipid comprising an amphiphilic cationic lipid to produce the lipid:nucleic acid complex. This complex can be further stabilized by the addition of a hydrophilic polymer attached to hydrophobic side chains. The complex can also be made specific for specific cells, by incorporating a targeting moiety such as an Fab' fragment attached to a hydrophilic polymer. The present invention further relates to lipidic microparticles with attached proteins which have been first conjugated to linker molecules having a hydrophilic polymer domain and a hydrophobic domain capable of stable association with the microparticle, or proteins which have been engineered to contain a hydrophilic domain and a lipid moiety permitting stable association with the microparticle.
Preparation Of Stable Formulations Of Lipid-Nucleic Acid Complexes For Efficient In Vivo Delivery
US Patent:
6071533, Jun 6, 2000
Filed:
Nov 10, 1997
Appl. No.:
8/967791
Inventors:
Demetrios Papahadjopoulos - San Francisco CA
Keelung Hong - San Francisco CA
Weiwen Zheng - San Francisco CA
Keelung Hong - San Francisco CA
Weiwen Zheng - San Francisco CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 9127
US Classification:
424450
Abstract:
The present invention provides for lipid:nucleic acid complexes that have increased shelf life and high transfection activity in vivo following intravenous injection, and methods of preparing such complexes. The methods generally involve contacting a nucleic acid with an organic polycation to produce a condensed nucleic acid, and then combining the condensed nucleic acid with a lipid comprising an amphiphilic cationic lipid to produce the lipid:nucleic acid complex. This complex can be further stabilized by the addition of a hydrophilic polymer attached to hydrophobic side chains. The complex can also be made specific for specific cells, by incorporating a targeting moiety such as an Fab' fragment attached to a hydrophilic polymer.
Preparation Of Stable Formulations Of Lipid-Nucleic Acid Complexes For Efficient In Vivo Delivery
US Patent:
6943027, Sep 13, 2005
Filed:
Apr 12, 2002
Appl. No.:
10/121962
Inventors:
Demetrios Papahadjopoulos - San Francisco CA, US
Keelung Hong - San Francisco CA, US
Weiwen Zheng - San Francisco CA, US
Keelung Hong - San Francisco CA, US
Weiwen Zheng - San Francisco CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
C12N015/88
US Classification:
435458, 514 44
Abstract:
The present invention provides for lipid:nucleic acid complexes that have increased shelf life and high transfection activity in vivo following intravenous injection, and methods of preparing such complexes. The methods generally involve contacting a nucleic acid with an organic polycation to produce a condensed nucleic acid, and then combining the condensed nucleic acid with a lipid comprising an amphiphilic cationic lipid to produce the lipid:nucleic acid complex. This complex can be further stabilized by the addition of a hydrophilic polymer attached to hydrophobic side chains. The complex can also be made specific for specific cells, by incorporating a targeting moiety such as an Fab′ fragment attached to a hydrophilic polymer.
Methods For Attaching Proteins To Lipidic Microparticles With High Efficiency
US Patent:
7022336, Apr 4, 2006
Filed:
May 17, 2004
Appl. No.:
10/847982
Inventors:
Demetrios Papahadjopoulos - San Francisco CA, US
Keelung Hong - San Francisco CA, US
Weiwen Zheng - San Francisco CA, US
Dmitri B. Kirpotin - San Francisco CA, US
Keelung Hong - San Francisco CA, US
Weiwen Zheng - San Francisco CA, US
Dmitri B. Kirpotin - San Francisco CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 9/127
US Classification:
424450, 435458, 435472
Abstract:
The invention provides methods of attaching proteins to lipidic microparticles with efficiencies of at least 77%. The proteins are attached to linker molecules comprising a hydrophilic domain and a hydrophobic domain. The proteins can be antibodies, antibody fragments, hormones, growth factors, enzymes, or nucleic acid binding proteins, or other proteins. The proteins can be chemically conjugated to the linker molecules, or they can be fused to the linker molecules by recombinant techniques.