Inventors:
Paul A. Marks - Washington CT, US
Weisheng Xu - Forest Hills NY, US
Mandana Namdar - New York NY, US
International Classification:
A61K 31/422, C12N 5/09, A61K 31/704, A61K 31/7048, A61K 31/195, A61P 35/00
US Classification:
514 27, 514575, 514 34, 514376, 435375
Abstract:
This invention provides methods for treating a subject afflicted with cancer, comprising concurrently administering (i) an HDAC 6-selective inhibitor and (ii) a suitable cytotoxic agent such as SAHA, doxorubicin or etoposide. This invention also provides methods for inducing the death of a transformed cell such as a cancer cell, comprising concurrently contacting the cell with (i) an HDAC 6-selective inhibitor and (ii) a suitable cytotoxic agent such as SAHA, doxorubicin or etoposide.