WEI-ZEN WEI
Pharmacy in Detroit, MI
License number
Michigan 5304000817
Issued Date
Oct 29, 2010
Expiration Date
Jun 30, 2017
Category
Pharmacy
Type
CS - Research Lab
Address
Address
Detroit, MI 48201
Professional information
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Vaccines Targeting Cellular Death Receptors
Vaccines Targeting Cellular Death Receptors
US Patent:
2012018, Jul 26, 2012
Filed:
Nov 6, 2009
Appl. No.:
13/128046
Inventors:
Wei-Zen Wei - Grosse Pointe Farms MI, US
Gen Sheng Wu - Troy MI, US
Marie P. Piechocki - Fraser MI, US
Richard F. Jones - Fayetteville NY, US
Gen Sheng Wu - Troy MI, US
Marie P. Piechocki - Fraser MI, US
Richard F. Jones - Fayetteville NY, US
International Classification:
A61K 39/00, A61P 35/00, G01N 33/53, A61P 37/04, A61K 39/395, G01N 21/64, A61K 39/39
US Classification:
424 851, 4241841, 436513, 4241921, 4242391, 4242041, 4242321, 4242331, 4242071, 4242571, 4242581, 4241721, 435 792
Abstract:
The invention provides therapeutics and methods to induce a mammalian host, including a human, to produce antibodies, which agonize death receptors and cause the apoptotic death of target cells within the host's body. The therapeutics are vaccine compositions, including genetic vaccines encoding death receptor antigens of the tumor necrosis factor receptor family. Also provided are means and methods for overcoming host immunological tolerance to death receptors. The vaccines are useful against cancer cells and other death receptor bearing target cells within the host, and can be used in both therapeutic and prophylactic settings. The vaccines are also useful for diagnostic testing of the immunocompetence of a host.