Inventors:
Shaomeng Wang - Saline MI, US
Yujun Zhao - Ann Arbor MI, US
Wei Sun - Ann Arbor MI, US
Sanjeev Kumar - Ann Arbor MI, US
Lance Leopold - Dresher PA, US
Laurent Debussche - Paris, FR
Cedric Barriere - Paris, FR
Jean-Christophe Carry - Paris, FR
Kwame Amaning - Paris, FR
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI
SANOFI - Paris
ASCENTA THERAPEUTICS, INC. - Malvern PA
International Classification:
A61K 31/407, A61P 35/00, A61P 35/02, C07D 487/10
Abstract:
Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.