WEI LIU, DMD
Dentist at Craven St, San Diego, CA
License number
California DN1856592
Category
Dentist
Type
General Practice
Address
Address
2310 Craven St BLDG 3230, San Diego, CA 92136
Phone
(347) 247-1867
Professional information
Novel Fusion Partners For The Purpose Of Crystallizing G-Protein Coupled Receptors
US Patent:
2012028, Nov 15, 2012
Filed:
May 11, 2012
Appl. No.:
13/470104
Inventors:
Michael A. HANSON - San Marcos CA, US
Christopher B. Roth - San Diego CA, US
Raymond C. Stevens - La Jolla CA, US
Joshua M. Kunken - San Diego CA, US
Mark T. Griffith - San Diego CA, US
Aaron A. Thompson - San Diego CA, US
Wei Liu - San Diego CA, US
Fei Xu - Palm Beach Gardens FL, US
Vsevolod Katritch - San Diego CA, US
Christopher B. Roth - San Diego CA, US
Raymond C. Stevens - La Jolla CA, US
Joshua M. Kunken - San Diego CA, US
Mark T. Griffith - San Diego CA, US
Aaron A. Thompson - San Diego CA, US
Wei Liu - San Diego CA, US
Fei Xu - Palm Beach Gardens FL, US
Vsevolod Katritch - San Diego CA, US
Assignee:
The Scripps Research Institute - La Jolla CA
RECEPTOS, INC. - San Diego CA
RECEPTOS, INC. - San Diego CA
International Classification:
C12N 9/96, G06F 17/30, C07K 19/00
US Classification:
435188, 530350, 707769
Abstract:
GPCR-fusion partner proteins comprising G protein coupled receptors (GPCRs) of GPCRs and fusion partners such as rubredoxin, cytochrome b562 RIL (Bril, bRIL, BRIL), T4 lysozyme C-terminal fragment (Cterm-T4L), flavodoxin, or xylanase either substituted for some or all of the third intracellular loop of the GPCR between the fifth and sixth helix of the GPCR are described or attached to an terminus or C terminus of the GPCR. GPCR-fusion partner proteins in crystalline form, optionally of a quality suitable for x-ray crystallographic structure determination of the GPCR, are described. Methods of using fusion partners in GPCR-fusion partner proteins to support crystallization of GPCR-fusion partner proteins for x-ray crystallographic structure determination of the GPCR, are described. Methods of identifying other suitable fusion partners through screening of protein data banks are also described.
Inhibitors Of Hepatitis C Virus, Compositions And Treatments Using The Same
US Patent:
2004022, Nov 18, 2004
Filed:
Feb 18, 2004
Appl. No.:
10/782679
Inventors:
Rohit Duggal - San Diego CA, US
Koleen Herlihy - San Diego CA, US
Wei Liu - San Diego CA, US
Amy Patick - Escondido CA, US
Eiann Sha - San Diego CA, US
Weidong Hao - San Diego CA, US
Koleen Herlihy - San Diego CA, US
Wei Liu - San Diego CA, US
Amy Patick - Escondido CA, US
Eiann Sha - San Diego CA, US
Weidong Hao - San Diego CA, US
Assignee:
AGOURON PHARMACEUTICALS, INC.
International Classification:
A61K038/05, A61K031/4965
US Classification:
514/018000, 514/255050
Abstract:
The invention relates to methods of inhibiting HCV viral replication activity comprising contacting an HCV polymerase with a therapeutically effective amount of a hydroxamate MMP inhibitor, and compositions comprising the same.