Inventors:
Wei Zhang - Houston TX, US
Wei Song - Houston TX, US
Greg Fuller - Houston TX, US
International Classification:
A61K048/00, A61K038/17, A01K067/027, C12Q001/68, G01N033/574, C12P021/02, C12N005/06, C07K014/47
US Classification:
435/006000, 435/007230, 435/069100, 435/320100, 435/325000, 514/044000, 514/012000, 530/350000, 536/023200, 800/018000
Abstract:
The present invention provides the identification of a tumor suppressor protein that binds to IGFBP2. This 388 amino acid protein, designated 86, contains an ICE-p20 domain, and is expressed in a number of normal tissues, include spleen, placenta, stomach, brain (including cerebellum) and liver. It also is expressed, ocassionally with a splice variant lacking a single exon, in various cancer cells including gliomas. Thus, methods for diagnosing and treating cancers having defects in the 86 gene are disclosed, as are methods for screening compounds for their ability to modulate 86 expression and function.