Inventors:
Ian Foltz - Burnaby, CA
Chadwick King - North Vancouver, CA
Peter Koon Bong Ling - Vancouver, CA
Jaspal Singh Kang - Surrey, CA
Kathy Manchulenko - Port Coquitlam, CA
Francine Chen - San Francisco CA, US
Caroline Darne Scatena - Alameda CA, US
Bruce A. Keyt - Hillsborough CA, US
Edwin Madison - San Francisco CA, US
Wayne R. Godfrey - Bainbridge Island WA, US
Stanislaw K. Morkowski - Lake Forest Park WA, US
Jennifer H. Richardson - Fremont CA, US
Assignee:
Amgen Fremont Inc. - Fremont CA
Dendreon Corporation - Seattle WA
International Classification:
A61K 39/395, A61K 51/00, C07H 21/04, C12N 5/06, C12P 21/06
US Classification:
4241331, 424 149, 4241551, 4353201, 435338, 435 691, 536 2353
Abstract:
Binding proteins, such as fully human monoclonal antibodies and fragments thereof, directed to the antigen Matriptase and uses of such binding proteins are disclosed. Nucleotide sequences encoding, and amino acid sequences comprising heavy and light chain immunoglobulin molecules capable of binding to Matriptase are also disclosed. The invention also discloses cell lines expressing such immunoglobulin molecules and monoclonal antibodies to Matriptase. The antibodies can be used to detect, prevent, and treat diseases such as cancer.