WAYNE J WALLIS, MD
Osteopathic Medicine at Federal Ave, Seattle, WA

2008026, Oct 23, 2008

Mar 27, 2008

12/057133

Rafael A. Ponce - Seattle WA, US
Wayne J. Wallis - Seattle WA, US
Matthew S. Holdren - Seattle WA, US
Linda Zuckerman - Seattle WA, US
Alisa M. Littau - Woodinville WA, US
Kirk P. Van Ness - Bainbridge Island WA, US
Claudia Pena Rossi - Geneva, CH
Hans Otto Lennart Graffner - Helsingborg, SE

A61K 39/395, A61P 37/00

4241341

The invention relates to novel combination therapies involving BLyS or BLyS/APRIL inhibition and immunosuppressants for the treatment of autoimmune diseases. One preferred method is where the BLyS and/or APRIL antagonist is a Fc-fusion protein which can be a TACI-Fc-fusion protein comprising the extracellular domain of TACI or a functional fragment thereof, a BAFF-R-Fc-fusion protein comprising the extracellular domain of BAFF-R or a functional fragment thereof, or a BCMA-Fc-fusion protein comprising the extracellular domain of BCMA or a functional fragment thereof. In the methods of the present invention some of the immunosuppressive drugs contemplated include cyclophosphamide (CYC), azathioprine (AZA), cyclosporine A (CSA), or mycophenolate mofetil (MMF), although any drug that suppresses the immune system may be suitable. The methods of the present invention reduce the levels of various immunoglobulins in patients in need of such reduction, such as those suffering from autoimmune diseases.