Inventors:
Warren S. Pear - Philadelphia PA, US
Karen Keeshan - Philadephia PA, US
Yiping He - Phildephia PA, US
International Classification:
A61K 39/395, C12Q 1/68, G01N 33/68, C12N 5/078, A61K 38/02, A61K 31/7105, A61K 31/7088, A61P 35/02
US Classification:
4241731, 435 6, 435 724, 435375, 514 11, 514 44 A, 514 44 R, 514 196
Abstract:
Provided are methods for the diagnosis and treatment of acute myelogenous leukemia. In particular, the present invention relates to the use of Trib2 polynucleotides and polypeptides for the diagnosis and treatment of acute myelogenous leukemia (AML) by assessing myeloid cells of a patient, or malignancies associated with Trib2, C/EBPαp30 or C/EBPαp42, such as AML or lung cancer, by assessing hematopoietic stem cells of the patient.