Inventors:
Ravi Thadhani - Boston MA, US
S. Ananth Karumanchi - Chestnut Hill MA, US
Eliyahu Khankin - Boston MA, US
Walter P. Mutter - West Newton MA, US
Assignee:
BETH ISRAEL DEACONESS MEDICAL CENTER, INC. - Boston MA
THE GENERAL HOSPITAL CORPORATION - Boston MA
International Classification:
A61K 39/395, A61P 3/00, A61K 38/18, G01N 33/566, C12Q 3/00
US Classification:
4241391, 435 792, 436501, 435 71, 435 3, 514 77
Abstract:
The methods described herein can be used to identify ex ante which hemodialysis patients are likely to develop EPO resistance and therefore will require additional rHu EPO, and to provide treatments that can reduce the need for additional rHu EPO. In addition, the methods can be used to predict which subjects have a higher risk of mortality, to identify high-risk patients who can then be monitored more closely or treated more aggressively. Also provided are kits for carrying out the described methods.